Destinations > Southern and Midwest

    The South & Midwest

    Welcome to the South with all its great hospitality, historic buildings, and smells of Southern cooking. A place of history and charm that is very popular for all ages... You can choose to visit the Historic Plantations of long ago, Civil War battlefields and museums, fabulous historic Jazz clubs, Paula Dean's "Two Sons restaurant" in Savannah, or taste Cajun jambalaya and Creole gumbo in New Orleans. Then we have our Mid-Western destinations, such as St. Louis, home of the famous Arch or the peacefulness of Amish Country. The natural beauty here is breathtaking, from Saint Anthony falls to the fall foliage colors of the upper Mississippi river. This is the place of Mark Twain's America in all its glory. When cruising between St. Louis and St. Paul you will pass thru 29 locks, something unbelievable to experience!

    Along the way to either of these destinations USA River Cruises will be there to make sure your trip is filled with wonderful memories!!

    South and Midwest Itineraries

    Adventure on the Mississippi *NEW*
    Memphis to Nashville small ship cruise

    Discover North America's longest and most famous river in two incredible journeys that reveal breathtaking scenery, some of the United States' most charming cities, amazing history, and much more, including stretches of the picturesque Ohio and Cumberland Rivers.

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    Jacksonville to Alexandria
    Jacksonville to Alexandria small ship cruise

    Starting in Florida and cruising northward to Virginia, this adventure takes you up-close to some of the United States' most beautiful and historic cities. You'll delight in astounding architecture, magnificent parks, and fascinating landmarks in regions discovered and settled by European explorers centuries ago.

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    Chicago to the Big Easy
    Chicago to the Big Easy small ship cruise

    The heart of mid-America can be found along the mighty Mississippi region between New Orleans and Chicago. Travel eight rivers as you navigate this historic part of our country.

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    Culture and Traditions: Charleston to the Chesapeake
    Culture and Traditions: Charleston to the Chesapeake small ship cruise

    Cruise for 10 days from Charleston, SC along the coast with stops in both North and South Carolina and Norfolk, Virginia. After that you'll journey up through the Chesapeake Bay to Philadelphia.

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    Historic Steamboat Cruises
    Peoria to St. Louis small ship cruise

    Choose from two itineraries aboard the Spirit of Peoria, a full-blown replica of the nineteenth century riverboats that used to inhabit the nation's waterways.

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    Spirit of Peoria & the Land of Lincoln
    Spirit of Peoria & the Land of Lincoln small ship cruise

    Ride along America’s first "superhighways:" Route 66, the Illinois and the Mississippi Rivers! Along the way you’ll get to know Abraham Lincoln’s beloved city of Springfield, Illinois, discover St. Louis from the top of the Gateway Arch and cruise aboard the nostalgic paddlewheeler Spirit of Peoria.

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    American Heartland River Cruise
    American Heartland River Cruise Map

    Discover the heart of mid-America on this 14-night cruise along the mighty Mississippi region between New Orleans and Chicago. Travel eight rivers as you navigate this historic part of our country.

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    The Great Lakes

    Travel America's magnificent Inland Sea aboard the 100-guest Clelia, from Toronto to Duluth or reverse. Mackinac Island, Welland Canal, Manitoulin Island are just some of the wonders you'll experience on this 8-day, 7-night adventure. All gourmet meals, wine with dinner, and drinks are included.

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    The Great Lakes Golf Cruise

    Discover spans of pristine splendor and world class golf courses aboard the Clelia on this 8-day, 7-night cruise. Golfers will revel in such world-class venues as the Grand Niagara Resort and Cobble Beach Golf Links. All gourmet meals, wine with dinner, and drinks are included.

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    Lake Michigan Getaway
    Lake Michigan Getaway small ship cruise

    Circumnavigating Lake Michigan gives one the opportunity to truly explore the offerings of the only Great Lake entirely in the United States. Marvel at its natural beauty and friendly Midwestern villages and cities.

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    U.S. Historic Rivers
    U.S. Historic Rivers

    Explore the beauty of America's interior waterways between the Gulf of Mexico and Lake Michigan in three distinctive legs that can be taken individually or collectively.

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    Great Rivers of Florida
    Great Rivers of Florida small ship cruise

    Cruise the serene waters of St. Johns River and enjoy the brilliance and beauty of its islands, seaports and cities, experiencing a side of Florida few others do.

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    Historic South & Golden Isles

    Glittering bays, elegant mansions, moss-draped oaks, abundant wildlife and remote islands lend to the grace and enchantment that is distinctly Antebellum South. Take in the spectacular scenery while gliding through the Ashepoo, Stono and Ashley Rivers and St. Catherine's Sound, and enjoy the history and culture of each port along the way.

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    The Route of Jean Lafitte

    Between New Orleans and Galveston, Texas and Port Isabel, Texas along the Intracoastal Waterway, explore explore the territory of the daring buccaneer who helped defeat the British in the Battle of New Orleans. From his base at Grand Terre Island on the edge of the expansive Barataria Swamp, "The Gentleman Pirate" commanded a force of over 1,000 privateers and fifty ships.

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    Delta South

    Like twin sisters separated at birth, New Orleans and Memphis are modern heirs to a legacy we call the Delta South. Linked by the river and the cotton it carried, these cities have wonderful stories to share. Today, the river carries more than cotton. See it all. Ships from many nations, flying many flags, carrying cargo to every corner of the earth.

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    Cajuns and Creoles

    Today's Cajuns, a derived pronunciation of "Acadians," are a vibrant culture who have fiercely held onto their language, food and music. Traveling through the Atchafalaya River Basin- America's greatest freshwater swamp-we'll come face-to-face with a culture that is as unique and interesting as can be found anywhere in this world.

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    Southern Antebellum
    Southern Antebellum small ship cruise

    Enjoy the rich history, natural beauty and southern hospitality of the fascinating segment of the Southeastern U.S. Intracoastal Waterway.

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    The Arch and the Pyramid

    The gleaming Gateway Arch in St. Louis towers over the river symbolizing America's opening of the west to commerce and settlement. The Pyramid in Memphis is a totem comparing ancient Egypt's advanced society with our own. These are just two of the many sights to see traveling the Mississippi in a region called The Arch and The Pyramid.

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    Expanding Frontiers

    The Cumberland River Valley. In a region of the United States where fiddles and banjoes are as much a part of local color as muskets and coonskin caps, we offer excursions that are perfect adventures to share with friends and family. Feel, firsthand, the challenges of frontier life as lived by the first Europeans to inhabit this region.

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