Complete Mississippi River – American Melody

Sailing on American Melody

There is nothing as epic as spending a full three weeks cruising the entire length of the Mississippi River! From New Orleans to St. Paul, you’ll be blown away by the beauty, history, and cultures that you’ll experience as you cruise north.

With only one departure date available per year, your preferred stateroom could be taken at any moment. Book early to secure your passage aboard the ‘America‘! Cruising the Mississippi River does include big cities like New Orleans, Memphis, St. Louis and St. Paul.

But you also get to stop in small towns that were once vital to the westward-growing United States, like Vicksburg, Red Wing, Paducah, Natchez and more. And the ‘America‘ will stop in even smaller areas for their natural beauty or cultural importance, like Oak Alley, Cape Girardeau, and Hannibal.

Cruise Details

Complimentary Airfare!!!

23 Days / 22 Nights
from $20,199
from $15,890*

*Per person for double occupancy. Special single rates apply where listed. Excludes port fees. Itineraries may operate in reverse.

Itinerary & Excursions

Exact itinerary & excursions will vary by cruise date.

Day 1 — New Orleans, LA (Pre-Cruise Hotel)

Each Mississippi itinerary comes complete with a Hotel Stay, providing you with a seamless way to board the ship and explore the local area. On the morning of the cruise, meet in the hotel lobby and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.

Meals: D

American Melody

  • Up to 180 guests
  • Small Ship
  • Est. 2021
The American Melody is a modern 180-guest riverboat featuring 91 spacious staterooms, elegant dining venues with panoramic views, and expansive sun deck seating for a comfortable and scenic cruising experience.

Cabin Categories


Cabin Price
Grand Suite (GS) $27,915 pp
Veranda Suite (VS) $21,790 pp
Premium Balcony (PB) $18,540 pp
Deluxe Balcony (DB1) $17,495 pp
Standard Balcony (SB1) $15,890 pp
Single Balcony (SBG) $20,200
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Complete Mississippi River – American Melody FAQ

What is included in my cruise fare?

Your cruise fare typically includes your accommodations, onboard meals, entertainment, and many onboard amenities. Depending on the cruise line and itinerary, your fare may also include guided excursions, beverages, Wi-Fi, gratuities, airport transfers, or other special inclusions. Your USA River Cruises travel advisor can explain exactly what’s included with your selected voyage.

When is the best time to book a cruise?

The best time to book is as early as possible, especially for popular itineraries, holiday sailings, and peak travel seasons. Booking early often provides the best selection of staterooms, preferred sailing dates, and access to limited-time promotions or early booking discounts.

How do I choose the right stateroom?

The ideal stateroom depends on your budget, travel style, and personal preferences. Interior, oceanview, balcony, and suite accommodations each offer different amenities and views. If you’re unsure which option is best, our cruise specialists can help you compare accommodations and recommend the best fit for your vacation.

Are shore excursions included?

Many cruises include one or more guided shore excursions, while others offer optional experiences that can be added to your itinerary. Excursion availability varies by cruise line and destination, and many can be reserved before your departure.

Do I need travel insurance?

Travel insurance is highly recommended for every cruise vacation. It can help protect your investment in case of trip cancellations, travel delays, medical emergencies, lost luggage, or other unexpected events. Our team can discuss available coverage options when you book.

Why should I book through USA River Cruises?

When you book with USA River Cruises, you’ll receive personalized guidance from experienced cruise specialists who can help you compare itineraries, cruise lines, ships, and current promotions. We’ll help you find the best value, answer your questions before and after booking, and provide dedicated support throughout your travel planning experience.