Grand Heartland Cruise – American Melody

Sailing on American Melody

Time to Check ‘Mississippi River’ Off Your Bucket List!

Are you ready to cruise the entire length of the Mississippi River? You may have cruised segments before, but nothing can compare to experiencing the full Mississippi in one cruise. This 15-night southbound cruise is offered a couple times a year, and cannot be missed. You’ll cruise down the epic river of lore, as well as paddle past 10 states!

Cruise Details


16 Days / 15 Nights
from $15,185
from $12,620*

*Per person for double occupancy. Special single rates apply where listed. Excludes port fees. Itineraries may operate in reverse.

Itinerary & Excursions

Exact itinerary & excursions will vary by cruise date.

Day 1 — Embark in St. Paul, MN

Take some time to explore the Twin Cities before boarding your boat. Perhaps a walking tour of Summit Avenue to enjoy the late 1800 historic mansions, or a visit to local art galleries and museums.

Meals: D

American Melody

  • Up to 180 guests
  • Small Ship
  • Est. 2021
The American Melody is a modern 180-guest riverboat featuring 91 spacious staterooms, elegant dining venues with panoramic views, and expansive sun deck seating for a comfortable and scenic cruising experience.

Cabin Categories


Cabin Price
Grand Suite (GS) $22,170 pp
Veranda Suite (VS) $17,310 pp
Premium Balcony (PB) $14,730 pp
Deluxe Balcony (DB) $13,900 pp
Standard Balcony (SB1) $12,620 pp
Single Balcony (SGB) $15,185
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Grand Heartland Cruise – American Melody FAQ

What is included in my cruise fare?

Your cruise fare typically includes your accommodations, onboard meals, entertainment, and many onboard amenities. Depending on the cruise line and itinerary, your fare may also include guided excursions, beverages, Wi-Fi, gratuities, airport transfers, or other special inclusions. Your USA River Cruises travel advisor can explain exactly what’s included with your selected voyage.

When is the best time to book a cruise?

The best time to book is as early as possible, especially for popular itineraries, holiday sailings, and peak travel seasons. Booking early often provides the best selection of staterooms, preferred sailing dates, and access to limited-time promotions or early booking discounts.

How do I choose the right stateroom?

The ideal stateroom depends on your budget, travel style, and personal preferences. Interior, oceanview, balcony, and suite accommodations each offer different amenities and views. If you’re unsure which option is best, our cruise specialists can help you compare accommodations and recommend the best fit for your vacation.

Are shore excursions included?

Many cruises include one or more guided shore excursions, while others offer optional experiences that can be added to your itinerary. Excursion availability varies by cruise line and destination, and many can be reserved before your departure.

Do I need travel insurance?

Travel insurance is highly recommended for every cruise vacation. It can help protect your investment in case of trip cancellations, travel delays, medical emergencies, lost luggage, or other unexpected events. Our team can discuss available coverage options when you book.

Why should I book through USA River Cruises?

When you book with USA River Cruises, you’ll receive personalized guidance from experienced cruise specialists who can help you compare itineraries, cruise lines, ships, and current promotions. We’ll help you find the best value, answer your questions before and after booking, and provide dedicated support throughout your travel planning experience.