Grand Heartland Cruise-American Serenade

Time to Check ‘Mississippi River’ Off Your Bucket List!
Are you ready to cruise the entire length of the Mississippi River? You may have cruised segments before, but nothing can compare to experiencing the full Mississippi in one cruise. This 14-night southbound cruise is offered a couple times a year, and cannot be missed. You’ll cruise down the epic river of lore, as well as paddle past 10 states!

15 Days & 14 Nights

Double Occupancy from $11,255 pp/do*

Single Occupancy from $14,290 pp

October 12, 2023 | September 18, 2024

Ship American Serenade

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*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

1Embark in St. Paul, MN
Take some time to explore the Twin Cities before boarding your boat. Perhaps a walking tour of Summit Avenue to enjoy the late 1800 historic mansions, or a visit to local art galleries and museums.

2Red Wing, MN
Red Wing is a fantastic river town with much to explore. Take a bald eagle viewing cruise with Captain Rusty. Or tour the town on the Red Wing Trolley to visit local shops, art galleries, and antique stores. Or tour the Red Wing Pottery workshop, where they’ve been producing stoneware for three generations.

3La Crosse, WI
Enjoy the day at Riverside Park, where the Black River and La Crosse River join the Mississippi waters. Surrounding the town are the 500 ft bluffs including the Grandad Bluff mentioned by Mark Twain in his ‘Life on the Mississippi’.

4Dubuque, IA
One of the oldest settlements west of the Mississippi, Dubuque is a fascinating town full of just about everything. The complimentary shore excursion includes a historic city tour. Dubuque has Victorian era attractions, and you’ll learn about the history of this beautiful town with stops at Mathias Ham House and the Old Jail Museum.

5Davenport, IA
The complimentary shore excursion in Davenport visits the John Deere Pavilion and store. Learn the story of the company, and how John Deere continues to contribute to agricultural development. Another option in town is to visit the John Hauberg Indian Museum in the Black Hawk State Historic Site.

6River Cruising

7Hannibal, MO
Learn all about the beginnings of the great Mark Twain in his boyhood hometown of Hannibal. Be sure to also visit the Interpretive Center, which houses 15 original Normal Rockwell paintings!

8St. Louis, MO
Explore the city, from the Gateway Arch on the riverfront to the Anheuser Busch Brewery stables to Forest Park.

9River Cruising

10Memphis, TN
Visit historic Beale Street to hear the beat of ‘Blues City’ or head over to Graceland to pay tribute to the King of Rock and Roll, Elvis Presley!

11River Cruising

12Vicksburg, MS
You cannot visit Vicksburg without touring the Battle of Vicksburg location, now a National Military Park. You’ll see the restored gunboat, the USS Cairo, as well as walk the battlefield of the Siege of Vicksburg.

13Natchez, MS
Enjoy a private city tour with a local expert guide who can point out the influences of different people, from the indigenous Native American to the European and African cultures. Other optional activities for today include an exclusive piano concert in the JN Stonehouse, or a tour of the Frogmore Plantation where you’ll be able to pick cotton from the fields and witness the technology that creates 900 bales-per-day.

14Baton Rouge, LA
Beginning at the Louisiana Old State Capitol, you’ll enjoy the exclusive tour of the Old and New State Capitols, with expansive views of the Mississippi River you’ve been cruising these last two weeks. You can choose to continue your day touring the Rosedown Plantation or the Cajun Heritage & Rural Life Museum – both offering views of antebellum life in the South.

15Disembark in New Orleans, LA
Disembark after breakfast.

Map & Gallery

Cabin Categories

Cabin	Single Price	Double Price
Grand Suite (Private Balcony)	—	$21,635 pp
Veranda Suite (Private Balcony)	—	$15,570 pp
AAM (Private Balcony)	—	$13,870 pp
AAC (Private Balcony)	—	$12,975 pp
AAR (Private Balcony)	—	$11,255 pp
Single (Private Balcony)	$14,290	—

Ship Read more about the American Serenade

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

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