Grand Ohio River Cruise – American Melody

Sailing on American Melody

Time to cruise east, leaving the familiar Mississippi behind for the Ohio River! Follow the history of the pioneers who kept pushing the boundaries of American identity in music, culture, architecture, and more. From St. Louis to Pittsburgh (or reverse), this Ohio River cruise will introduce you to the heartland of America. From the start of the cruise in St. Louis, you’ll pick up the rhythm of the river.

The Queen of the Mississippi will continue that rhythm with the churning paddlewheel and joyful noise of the calliope! Journeying southeast, you’ll visit Paducah, where the Tennessee and Ohio Rivers come together.

Where waters meet, so do people, making Paducah rich in history. Walk among the bronze ‘Birds of America’ statues in Henderson, based on the paintings of John James Audubon. Feel the spirit of the South alive in the northern Louisville. Walk through history along the river’s edge. Continue your 11-Day cruise northeast through ports of call in Ohio and Kentucky before disembarking in Pittsburgh, Pennsylvania.

Pittsburgh | Marietta | Maysville | Cincinnati | Louisville | Henderson | Paducah | Cape Girardeau | St. Louis

Cruise Details


16 Days / 15 Nights
from $11,745
from $9,245*

*Per person for double occupancy. Special single rates apply where listed. Excludes port fees. Itineraries may operate in reverse.

Itinerary & Excursions

Exact itinerary & excursions will vary by cruise date.

Day 1 — Pittsburgh, PA

Welcome aboard the American Heritage! This itinerary includes a complimentary pre-cruise hotel stay in Pittsburgh!

Meals: D

American Melody

  • Up to 180 guests
  • Small Ship
  • Est. 2021
The American Melody is a modern 180-guest riverboat featuring 91 spacious staterooms, elegant dining venues with panoramic views, and expansive sun deck seating for a comfortable and scenic cruising experience.

Cabin Categories


Cabin Price
Grand Suite (GS) $16,230 pp
Veranda Suite (VS) $12,675 pp
Premium Balcony (PB) $10,785 pp
Deluxe Balcony (DB) $10,175 pp
Standard Balcony (SB1) $9,245 pp
Single Balcony (SGB) $11,745
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Grand Ohio River Cruise – American Melody FAQ

What is included in my cruise fare?

Your cruise fare typically includes your accommodations, onboard meals, entertainment, and many onboard amenities. Depending on the cruise line and itinerary, your fare may also include guided excursions, beverages, Wi-Fi, gratuities, airport transfers, or other special inclusions. Your USA River Cruises travel advisor can explain exactly what’s included with your selected voyage.

When is the best time to book a cruise?

The best time to book is as early as possible, especially for popular itineraries, holiday sailings, and peak travel seasons. Booking early often provides the best selection of staterooms, preferred sailing dates, and access to limited-time promotions or early booking discounts.

How do I choose the right stateroom?

The ideal stateroom depends on your budget, travel style, and personal preferences. Interior, oceanview, balcony, and suite accommodations each offer different amenities and views. If you’re unsure which option is best, our cruise specialists can help you compare accommodations and recommend the best fit for your vacation.

Are shore excursions included?

Many cruises include one or more guided shore excursions, while others offer optional experiences that can be added to your itinerary. Excursion availability varies by cruise line and destination, and many can be reserved before your departure.

Do I need travel insurance?

Travel insurance is highly recommended for every cruise vacation. It can help protect your investment in case of trip cancellations, travel delays, medical emergencies, lost luggage, or other unexpected events. Our team can discuss available coverage options when you book.

Why should I book through USA River Cruises?

When you book with USA River Cruises, you’ll receive personalized guidance from experienced cruise specialists who can help you compare itineraries, cruise lines, ships, and current promotions. We’ll help you find the best value, answer your questions before and after booking, and provide dedicated support throughout your travel planning experience.