Lower Mississippi River Cruise – American Melody

Sailing on American Melody

Explore historic and modern river life on this unique exploration of the Lower Mississippi River. Cruising from NOLA to Memphis, or reverse, you’ll catch the heartbeat of the river. Enjoy Cajun cuisine on the Mississippi Delta, and so much more!

Ports of call include: Oak Alley | Natchez | Baton Rouge | Vicksburg | St. Francisville | Memphis | New Orleans

Cruise Details


9 Days / 8 Nights
from $7,620
from $5,995*

*Per person for double occupancy. Special single rates apply where listed. Excludes port fees. Itineraries may operate in reverse.

Itinerary & Excursions

Exact itinerary & excursions will vary by cruise date.

Day 1 — New Orleans, LA

Settle into your hotel and enjoy a feast for your senses as you explore this magical city, renowned for its delicious cuisine, vibrant music scene, and rich culture with an international flair. Stroll the tree-lined avenues, take a carriage ride through the French Quarter, hop aboard a streetcar to the gorgeous Garden District, or visit the renowned National World War II Museum.

Meals: D

American Melody

  • Up to 180 guests
  • Small Ship
  • Est. 2021
The American Melody is a modern 180-guest riverboat featuring 91 spacious staterooms, elegant dining venues with panoramic views, and expansive sun deck seating for a comfortable and scenic cruising experience.

Cabin Categories


Cabin Price
Grand Suite (GS) $10,620 pp
Veranda Suite (VS) $8,290 pp
Premium Balcony (PB) $6,995 pp
Deluxe Balcony (DB1) $6,600 pp
Standard Balcony (SB1) $5,995 pp
Single Balcony (SGB) $7,620
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Lower Mississippi River Cruise – American Melody FAQ

What is included in my cruise fare?

Your cruise fare typically includes your accommodations, onboard meals, entertainment, and many onboard amenities. Depending on the cruise line and itinerary, your fare may also include guided excursions, beverages, Wi-Fi, gratuities, airport transfers, or other special inclusions. Your USA River Cruises travel advisor can explain exactly what’s included with your selected voyage.

When is the best time to book a cruise?

The best time to book is as early as possible, especially for popular itineraries, holiday sailings, and peak travel seasons. Booking early often provides the best selection of staterooms, preferred sailing dates, and access to limited-time promotions or early booking discounts.

How do I choose the right stateroom?

The ideal stateroom depends on your budget, travel style, and personal preferences. Interior, oceanview, balcony, and suite accommodations each offer different amenities and views. If you’re unsure which option is best, our cruise specialists can help you compare accommodations and recommend the best fit for your vacation.

Are shore excursions included?

Many cruises include one or more guided shore excursions, while others offer optional experiences that can be added to your itinerary. Excursion availability varies by cruise line and destination, and many can be reserved before your departure.

Do I need travel insurance?

Travel insurance is highly recommended for every cruise vacation. It can help protect your investment in case of trip cancellations, travel delays, medical emergencies, lost luggage, or other unexpected events. Our team can discuss available coverage options when you book.

Why should I book through USA River Cruises?

When you book with USA River Cruises, you’ll receive personalized guidance from experienced cruise specialists who can help you compare itineraries, cruise lines, ships, and current promotions. We’ll help you find the best value, answer your questions before and after booking, and provide dedicated support throughout your travel planning experience.