Mississippi Explorer Cruise – American Serenade
Set sail on this brand-new itinerary to explore exclusive ports along the Mississippi River. Your adventure begins in the vibrant city of New Orleans and sails effortlessly to Memphis. In the comfort of our brand-new riverboat, enjoy a leisurely day of cruising as the shores of the Mississippi Delta glide past.
Visit Oak Alley and Houmas House, where grandeur awaits amidst lush gardens and draping oak trees. Led by our engaging guides, explore the historic landmarks of Baton Rouge, Louisiana’s capital city, and learn about the storied past of St. Francisville. In Natchez, Mississippi’s oldest city, explore the city’s meticulously preserved mansions such as Historic Longwood.
Cruise Details
*Per person for double occupancy. Special single rates apply where listed. Excludes port fees. Itineraries may operate in reverse.
Itinerary & Excursions
Exact itinerary & excursions will vary by cruise date.
Day 1 — New Orleans, LA
Settle into your room at the Four Seasons Hotel New Orleans and enjoy this magical city, renowned for its delicious cuisine, vibrant music scene, and rich culture with an international flair. Stroll the tree-lined avenues, take a carriage ride through the French Quarter, hop aboard a streetcar to the gorgeous Garden District, or visit the renowned National World War II Museum.
Meals: D
American Serenade
- Up to 180 guests
- Small Ship
- Est. 2023
Cabin Categories
| Cabin | Price |
|---|---|
| Grand Suite (GS) | $13,690 pp |
| Veranda Suite (VS) | $10,690 pp |
| Premium Balcony (PB) | $9,020 pp |
| Deluxe Balcony (DB1) | $8,555 pp |
| Standard Balcony (SB1) | $7,770 pp |
| Single Balcony (SGB) | $9,875 |
“Cindy I can not thank you enough. We were able to visit my parents on the American Queen at one of their stops. We got to see the boat and their room. The boat…”
Read more
“It (the New Year’s Eve Cruise on the American Queen) was one of the best cruise we have ever gone on. The tour group Jazz Dagen had 240 jazz fans on with their favorite musicians. …”
Read more
“My husband and I recently sailed on the Niagara Prince from New Orleans to Chicago. We had a wonderful time and wanted to pass on our appreciation for the excellent work of the crew. …”
Read more

Mississippi Explorer Cruise – American Serenade FAQ
What is included in my cruise fare?
Your cruise fare typically includes your accommodations, onboard meals, entertainment, and many onboard amenities. Depending on the cruise line and itinerary, your fare may also include guided excursions, beverages, Wi-Fi, gratuities, airport transfers, or other special inclusions. Your USA River Cruises travel advisor can explain exactly what’s included with your selected voyage.
When is the best time to book a cruise?
The best time to book is as early as possible, especially for popular itineraries, holiday sailings, and peak travel seasons. Booking early often provides the best selection of staterooms, preferred sailing dates, and access to limited-time promotions or early booking discounts.
How do I choose the right stateroom?
The ideal stateroom depends on your budget, travel style, and personal preferences. Interior, oceanview, balcony, and suite accommodations each offer different amenities and views. If you’re unsure which option is best, our cruise specialists can help you compare accommodations and recommend the best fit for your vacation.
Are shore excursions included?
Many cruises include one or more guided shore excursions, while others offer optional experiences that can be added to your itinerary. Excursion availability varies by cruise line and destination, and many can be reserved before your departure.
Do I need travel insurance?
Travel insurance is highly recommended for every cruise vacation. It can help protect your investment in case of trip cancellations, travel delays, medical emergencies, lost luggage, or other unexpected events. Our team can discuss available coverage options when you book.
Why should I book through USA River Cruises?
When you book with USA River Cruises, you’ll receive personalized guidance from experienced cruise specialists who can help you compare itineraries, cruise lines, ships, and current promotions. We’ll help you find the best value, answer your questions before and after booking, and provide dedicated support throughout your travel planning experience.