St. Lawrence Seaway and Great Lakes Cruise

Sailing on Pearl Mist

On this comprehensive 15-night St. Lawrence Seaway & Great Lakes cruise, explore the breathtaking landscapes, historic harbors, and cosmopolitan cities that make this region incredible. Begin your journey in Quebec City, a living museum with nearly four centuries of history, before exploring the narrow cobblestone streets and alleyways of Montreal, admiring the splendid architecture of one of the oldest cities in North America.

Quebec City | Montreal | Toronto | Niagara Falls | Cleveland | Detroit | Mackinac Island | Holland | Milwaukee

Cruise Details


16 Days / 15 Nights
from $21,390
from $14,440*

*Per person for double occupancy. Special single rates apply where listed. Excludes port fees. Itineraries may operate in reverse.

Itinerary & Excursions

Exact itinerary & excursions will vary by cruise date.

Day 1 — Embark in Milwaukee, WI

Begin your journey in the vibrant city of Milwaukee. There’s more to this city than beer and baseball. In addition to being home to ten Fortune 1000 company headquarters, Milwaukee is also known for its historic architecture, markets, international seaport, and variety of museums, including the Milwaukee Art Museum just steps away from our dock.

Meals: D

Pearl Mist

  • Up to 210 guests
  • Small Ship
  • Est. 2014
The Pearl Mist is a luxury small ship offering spacious balcony staterooms, elegant dining, modern amenities, and advanced stabilization technology, providing a comfortable and refined cruising experience with more time to explore each destination.

Cabin Categories


Cabin Price
Veranda Suite (VS) $22,800 pp
Vista Balcony (VB) $18,490 pp
Premium Balcony (Private Balcony) $17,680 pp
Deluxe Balcony (DB) $14,970 pp
Standard Balcony (SB) $14,440 pp
Single Balcony 1 (Private Balcony) $22,530
Single Balcony 2 (Private Balcony) $21,390
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St. Lawrence Seaway and Great Lakes Cruise FAQ

What is included in my cruise fare?

Your cruise fare typically includes your accommodations, onboard meals, entertainment, and many onboard amenities. Depending on the cruise line and itinerary, your fare may also include guided excursions, beverages, Wi-Fi, gratuities, airport transfers, or other special inclusions. Your USA River Cruises travel advisor can explain exactly what’s included with your selected voyage.

When is the best time to book a cruise?

The best time to book is as early as possible, especially for popular itineraries, holiday sailings, and peak travel seasons. Booking early often provides the best selection of staterooms, preferred sailing dates, and access to limited-time promotions or early booking discounts.

How do I choose the right stateroom?

The ideal stateroom depends on your budget, travel style, and personal preferences. Interior, oceanview, balcony, and suite accommodations each offer different amenities and views. If you’re unsure which option is best, our cruise specialists can help you compare accommodations and recommend the best fit for your vacation.

Are shore excursions included?

Many cruises include one or more guided shore excursions, while others offer optional experiences that can be added to your itinerary. Excursion availability varies by cruise line and destination, and many can be reserved before your departure.

Do I need travel insurance?

Travel insurance is highly recommended for every cruise vacation. It can help protect your investment in case of trip cancellations, travel delays, medical emergencies, lost luggage, or other unexpected events. Our team can discuss available coverage options when you book.

Why should I book through USA River Cruises?

When you book with USA River Cruises, you’ll receive personalized guidance from experienced cruise specialists who can help you compare itineraries, cruise lines, ships, and current promotions. We’ll help you find the best value, answer your questions before and after booking, and provide dedicated support throughout your travel planning experience.