Upper Mississippi River Cruise – American Serenade
The Upper Mississippi River is prime location to discuss one of the greatest American authors and commentators in our history: Mark Twain! Not only will you be cruising the river he loved so dearly, you’ll be able to visit the important Tom Sawyer town of Hannibal. The boyhood home of Samuel Clemens (Mark Twain), Hannibal is a great small river town for you to explore. Visit the actual home he grew up in, surrounded by the whitewashed fence. You can also visit Becky Hatcher’s home and Huck Finn’s home, and take your picture with the Tom and Huck Statue on Cardiff Hill.
Ports of Call: St. Louis | Hannibal | Fort Madison | Davenport | Dubuque | Winona | Red Wing | St. Paul
Cruise Details
*Per person for double occupancy. Special single rates apply where listed. Excludes port fees. Itineraries may operate in reverse.
Itinerary & Excursions
Exact itinerary & excursions will vary by cruise date.
Day 1 — St. Louis, MO/Alton, IL
Welcome aboard the American Melody! We will transfer our guests from their pre-night hotel in St. Louis to Alton where we will board.
Meals: D
American Serenade
- Up to 180 guests
- Small Ship
- Est. 2023
Cabin Categories
| Cabin | Price |
|---|---|
| Grand Suite (GS) | $9,985 pp |
| Veranda Suite (VS) | $7,795 pp |
| Premium Balcony (PB) | $6,575 pp |
| Deluxe Balcony (DB1) | $6,205 pp |
| Standard Balcony (SB1) | $5,635 pp |
| Single Balcony (SGB) | $7,165 |
“Good Morning, Ali. Now that our Mississippi Cruise experience has ended I want to thank you for arranging the marvelous experience, effortless on our part, which we enjoyed from 5/17 to 5/26/24. The location…”
Read more
“My husband & I absolutely loved our recent trip on the American Queen from Memphis to New Orleans! The live entertainment & music was fabulous especially Deanna the cruise director & her 3 partners.…”
Read more
“This was an amazing trip! It started with the service we received from Nadine who patiently answered all of my questions right up to the day before we left. Once on board, we were…”
Read more
Upper Mississippi River Cruise – American Serenade FAQ
What is included in my cruise fare?
Your cruise fare typically includes your accommodations, onboard meals, entertainment, and many onboard amenities. Depending on the cruise line and itinerary, your fare may also include guided excursions, beverages, Wi-Fi, gratuities, airport transfers, or other special inclusions. Your USA River Cruises travel advisor can explain exactly what’s included with your selected voyage.
When is the best time to book a cruise?
The best time to book is as early as possible, especially for popular itineraries, holiday sailings, and peak travel seasons. Booking early often provides the best selection of staterooms, preferred sailing dates, and access to limited-time promotions or early booking discounts.
How do I choose the right stateroom?
The ideal stateroom depends on your budget, travel style, and personal preferences. Interior, oceanview, balcony, and suite accommodations each offer different amenities and views. If you’re unsure which option is best, our cruise specialists can help you compare accommodations and recommend the best fit for your vacation.
Are shore excursions included?
Many cruises include one or more guided shore excursions, while others offer optional experiences that can be added to your itinerary. Excursion availability varies by cruise line and destination, and many can be reserved before your departure.
Do I need travel insurance?
Travel insurance is highly recommended for every cruise vacation. It can help protect your investment in case of trip cancellations, travel delays, medical emergencies, lost luggage, or other unexpected events. Our team can discuss available coverage options when you book.
Why should I book through USA River Cruises?
When you book with USA River Cruises, you’ll receive personalized guidance from experienced cruise specialists who can help you compare itineraries, cruise lines, ships, and current promotions. We’ll help you find the best value, answer your questions before and after booking, and provide dedicated support throughout your travel planning experience.