Upper Mississippi River Cruise: St. Louis – St.Paul

The Upper Mississippi River is prime location to discuss one of the greatest American authors and commentators in our history: Mark Twain! Not only will you be cruising the river he loved so dearly, you’ll be able to visit the important Tom Sawyer town of Hannibal. The boyhood home of Samuel Clemens (Mark Twain), Hannibal is a great small river town for you to explore. Visit the actual home he grew up in, surrounded by the whitewashed fence. You can also visit Becky Hatcher’s home and Huck Finn’s home, and take your picture with the Tom and Huck Statue on Cardiff Hill.


St. Louis | Hannibal | Fort Madison | Davenport | Dubuque | Winona | Red Wing | St. Paul

Cruise Details

Clock8 Days & 7 Nights

Double Occupancy from $5,310 pp/do*

Single Occupancyfrom $6,740 pp

CalendarJune 30, 2023 | July 7, 2023 | July 14, 2023 | July 21, 2023 | July 28, 2023 | August 4, 2023
See 12 more available dates
August 11, 2023 | August 18, 2023 | August 25, 2023 | September 1, 2023 | September 8, 2023 | September 15, 2023 | September 22, 2023 | September 29, 2023 | October 6, 2023 | October 13, 2023 | September 21, 2024 | September 28, 2024

Book Now Request More Info

or call 800.578.1479

*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

    1St. Louis, MO/Alton, IL
    Welcome aboard the American Synphony! We will transfer our guests from their pre-night hotel in St. Louis to Alton where we will board.

    2Hannibal, MO
    Kick off your Mark Twain Tribute cruise in his boyhood hometown of Hannibal. Be sure to also visit the Interpretive Center, which houses 15 original Normal Rockwell paintings!

    3Fort Madison, IA
    Fort Madison offers visitors a vibrant cultural scene, bucolic landscapes, and an active agri-tourism industry which celebrates the American Heartland. Explore its many historic districts, where you can admire the well preserved Victorian and Post Renaissance architecture. Enjoy the area's museums, unique boutiques, antique shops, as well as the local breweries & wineries.

    4Davenport, IA
    Voted one of the "Most Livable small cities in America", Davenport is often described as a lively active city with a hometown feel. Music enthusiasts will enjoy Davenport's many music festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Fest.

    5Dubuque, IA
    One of the oldest settlements west of the Mississippi, Dubuque is a fascinating town full of just about everything. The complimentary shore excursion includes a historic city tour. Dubuque has Victorian era attractions, and you’ll learn about the history of this beautiful town with stops at Mathias Ham House and the Old Jail Museum.

    6Winona, MN
    Step into 19th-century America in Winona! Located in the picturesque bluff country on the Mississippi River. Explore this vibrant small town with the perfect blend of urban edge and old world charm.

    7Red Wing, MN
    Red Wing is a fantastic river town with much to explore. Take a bald eagle viewing cruise with Captain Rusty. Or tour the town on the Red Wing Trolley to visit local shops, art galleries, and antique stores. Or tour the Red Wing Pottery workshop, where they’ve been producing stoneware for three generations.

    8Disembark in St. Paul, MN
    After breakfast, transfer to the airport or extend your stay with a hotel package.


Cabin Categories

Cabin Single Price Double Price
Grand Suite (Private Balcony)$10,295 pp
Veranda Suite (Private Balcony)$7,450 pp
AAM (Private Balcony)$6,540 pp
AAC (Private Balcony)$6,120 pp
AAR (Private Balcony)$5,310 pp
Single (Private Balcony)$6,740

Ship Read more about the American Symphony

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

Book Today

Upper Mississippi River Cruise: St. Louis – St.Paul

Book Now Request More Info

or call 800.578.1479