Upper Mississippi River Cruise: St. Louis – St.Paul

The Upper Mississippi River is prime location to discuss one of the greatest American authors and commentators in our history: Mark Twain! Not only will you be cruising the river he loved so dearly, you’ll be able to visit the important Tom Sawyer town of Hannibal. The boyhood home of Samuel Clemens (Mark Twain), Hannibal is a great small river town for you to explore. Visit the actual home he grew up in, surrounded by the whitewashed fence. You can also visit Becky Hatcher’s home and Huck Finn’s home, and take your picture with the Tom and Huck Statue on Cardiff Hill. Baseball lovers will enjoy the opportunity to visit the Field of Dreams on a special premium shore excursion.


St. Louis | Hannibal | Fort Madison | Davenport | Dubuque | Winona | Red Wing | St. Paul

Cruise Details

Clock9 Days & 8 Nights

Double Occupancy from $5,545 pp/do*

CalendarSeptember 20, 2024 | September 27, 2024

Book Now Request More Info

or call 800.578.1479

*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

    1St. Louis, MO/Alton, IL
    Welcome aboard the American Synphony! We will transfer our guests from their pre-night hotel in St. Louis to Alton where we will board.

    2Cruising the Mississippi River
    Board your ship and be treated to a Welcome Reception. As you begin your amazing journey, relax on your private stateroom balcony and admire the beautiful views that stretch out before you. Get to know fellow guests in one of the lounges or at the evening cocktail hour.

    3Hannibal, MO
    Explore Hannibal, “America’s Hometown,” a mere block from the ship, where Mark Twain’s home and museum illuminate the events that shaped his life and career. Elements of his childhood adventures were woven into classics like The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn. Run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. Explore other nearby museums and the charming downtown Main Street with unique shops, art galleries, and tasty temptations.

    4Day of Cruising
    Curl up with a good book in one of our spacious lounges aboard the riverboat. Or relax on the sun deck or private balcony and enjoy the passing landscapes as we make our way along the Mississippi River.

    5Muscatine, IA
    Located in East Central Iowa, Muscatine County's eastern edge touches the banks of the Mighty Mississippi River and is the only place where this north to south river runs east to west. Perhaps Muscatine is best known for its history as the largest button manufacturing area in the world. Learn about this idyllic town’s rich past and revel in its natural beauty, led by our engaging local guides. Explore the charming downtown, located only two blocks from our dock, where you peruse local boutiques, coffee shops, and eateries.

    6Dubuque, IA
    A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the Mississippi River and continues today as a primary commercial, industrial, educational, and cultural center for this region. From the ship, it’s a short walk to a cruise highlight at the incredible complex of the Smithsonian-affiliated National Mississippi River Museum & Aquarium. View colorful Victorian mansions on a stroll through the quaint downtown area, take a ride on the world’s shortest and steepest scenic railway, or try your luck in one of Dubuque's state-of-the-art casinos. Visit one of the oldest catholic churches in the city and enjoy the lovely landscapes of the Dubuque Arboretum & Botanical Garden.

    7Winona, MN
    Winona welcomes you with the perfect blend of modern development and old river town charm. From rolling fields of flowers to some of the most architecturally important buildings in Minnesota, enjoy a carefully crafted selection of excursions which lead you through the most intriguing sites Winona has to offer. Explore a variety of history and art museums and admire historic homes, while listening to captivating stories told by a local guide. Board a self-exploration shuttle which takes you into the heart of downtown to learn, shop, eat, and stroll at your leisure.

    8Red Wing, MN
    Below the forested limestone bluffs of the upper Mississippi and along a narrow section of river channel, Red Wing snuggles among dozens of enchanting city parks. The town’s beauty has inspired artists, writers, and musicians for over 150 years, delivering a diverse blend of arts, entertainment, and activities for your pleasure. Explore the historic Sheldon Performing Arts Theatre, the home of famous Red Wing shoes, and the Pottery Museum, or ride up the bluff for a remarkable view. Visit the National Eagle Center to learn more about these incredible creatures with the added thrill of admiring them up close.

    9St. Paul, MN
    Enjoy easy access to the Minneapolis/St. Paul airport or extend your stay to further explore this enchanting area. The Twin Cities offer world-class art galleries, museums, and live performances. St. Paul’s Summit Avenue showcases gorgeous historic mansions built in the late 1800s. The enormous Mall of America includes more than 500 stores and an indoor waterpark and theme park. View gorgeous panoramas of the city from Mounds Park and cherish the enchantment of Minnehaha Falls with its 53-foot cascade.


Cabin Categories

Cabin Single Price Double Price
Grand Suite (Private Balcony)$10,530 pp
Veranda Suite (Private Balcony)$7,655 pp
AAM (Private Balcony)$6,530 pp
AAC (Private Balcony)$6,105 pp
AAR (Private Balcony)$5,545 pp
Single (Private Balcony)

Ship Read more about the American Symphony

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

Book Today

Upper Mississippi River Cruise: St. Louis – St.Paul

Book Now Request More Info

or call 800.578.1479