River Cruise Destinations

Discover America's most iconic waterways — from the storied Mississippi River to the majestic rivers of Alaska.

Browse Cruise Destinations

Alaska Cruises

The Last Frontier

Alaska Cruises

Glaciers and the Inside Passage

British Columbia Cruises

Salish Sea

British Columbia Cruises

Orcas, Victoria, and Butchart Gardens

California Coast Cruises

Channel Islands

California Coast Cruises

Channel Islands wildlife

Canada Cruises

Maritime North

Canada Cruises

All five Great Lakes and beyond

Chesapeake Bay Cruises

Early American History

Chesapeake Bay Cruises

D.C. to Baltimore history

Columbia River Cruises

Pacific Northwest

Columbia River Cruises

Gorges, vineyards, and history

East Coast Cruises

Eastern Seaboard

East Coast Cruises

Colonial towns and coastal heritage

European Cruises

Rivers & Coastlines

European Cruises

Danube, Rhine, and the Seine

Great Lakes Small Ship Cruises

The Sixth Sea

Great Lakes Small Ship Cruises

Niagara Falls to Mackinac Island

Hawaii Small Ship Cruises

All-Inclusive Islands

Hawaii Small Ship Cruises

All-inclusive island sailing

Hudson River Cruise from NYC

Fall Foliage

Hudson River Cruise from NYC

NYC to Albany in fall color

International Cruises

Around the World

International Cruises

Caribbean to the Galápagos

Lower Mississippi River Cruises

New Orleans to Memphis

Lower Mississippi River Cruises

New Orleans to Memphis blues

Midwest River Cruises

3,000 Miles of Waterway

Midwest River Cruises

3,000+ miles of waterways

Mississippi River Cruises

America's Great River

Mississippi River Cruises

New Orleans to Mark Twain country

New England Cruises

Harbors, History, Horizons

New England Cruises

Lighthouses to Quebec City

Northeast USA Cruises

Seafaring History

Northeast USA Cruises

Lighthouses and fall foliage

Ohio River Small Ship Cruises

Bourbon Country

Ohio River Small Ship Cruises

Pittsburgh to bourbon country

Pacific Northwest Cruises

Lewis & Clark Country

Pacific Northwest Cruises

Lewis and Clark country

Puget Sound Cruises Seattle

Washington State

Puget Sound Cruises Seattle

Islands, channels, and snow peaks

Southeast US Small Ship Cruises

Atlantic Intracoastal

Southeast US Small Ship Cruises

Savannah to the Florida coast

Tennessee, Cumberland, & Arkansas River Small Ship Cruises

Music City Country

Tennessee, Cumberland, & Arkansas River Small Ship Cruises

Memphis to Chattanooga music

Upper Mississippi River Cruises

Mark Twain Country

Upper Mississippi River Cruises

St. Louis to St. Paul bluffs

USA Cruises

Coast to Coast

USA Cruises

Coast to coast small ship sailing

Find Your Cruise Destination

USA River Cruises has been putting travelers on the water since 1996, with itineraries ranging from 7-night river voyages in the American heartland to 22-night Mississippi River crossings, wildlife expeditions in the Galápagos and Baja California, polar voyages, European river circuits, and small ship island cruises in Hawaii and the Caribbean.

Domestic Program

The domestic program covers the Mississippi from New Orleans to St. Paul, the Columbia and Snake Rivers, the Ohio River, the Cumberland and Tennessee Rivers, the Hudson River in fall foliage season, the Chesapeake Bay, New England, the Southeast Intracoastal Waterway, the Great Lakes, the Channel Islands, the San Juan Islands and Puget Sound, and the Hawaiian Islands. Internationally, the program reaches the Caribbean, Baja California, Canada’s Atlantic Maritimes, Europe’s Rhine, Danube, and Seine, the Galápagos, Tahiti, Central America, and the polar regions. Browse the destination pages above or call 866-636-2865 and our agents will help you find the right fit.

Frequently Asked Questions

Does USA River Cruises only offer river cruises?

Despite the name, the program extends well beyond rivers. Coastal and island itineraries include the Channel Islands off Los Angeles, the San Juan Islands and Puget Sound in the Pacific Northwest, the Hawaiian Islands, the Caribbean, the Galápagos, the New England and Atlantic coastline, the Southeast Intracoastal Waterway, and polar expedition voyages in the Arctic and Antarctic. Rivers are the backbone of the domestic program, but the full catalog covers a wide range of waterway types.

How do I choose between a domestic and an international cruise?

For most first-time small ship cruisers, the domestic program is a strong starting point. American itineraries involve no passport, no international flight, and a cultural story that rewards close attention — Civil War history, Appalachian music, Lewis and Clark country, fall foliage, and wildlife. International itineraries tend to appeal to travelers who have done the domestic routes or who have a specific destination in mind. Call 800-578-1479 and our agents can help you narrow it down based on how much time you have and what kind of experience you are looking for.

What is the difference between a river cruise and an expedition cruise?

River cruises sail inland waterways with a port call most days, typically covering a fixed corridor between two cities over 7 to 22 nights. Expedition cruises are wildlife and nature focused, operating in more remote environments — the Galápagos, Baja California, the polar regions, the Channel Islands, Hawaii — with days built around guided shore outings, snorkeling, and naturalist programming rather than historic port towns. Both use small ships; the experience and pace differ significantly.

Are these cruises all-inclusive?

Most itineraries in the program are all-inclusive or close to it, with meals, excursions, and onboard programming included in the fare. The specifics vary by ship and itinerary. Our agents will walk you through exactly what is and isn't included on any sailing before you book.

How far in advance should I book?

It depends on the destination and time of year. Fall foliage sailings on the Hudson River and in New England fill earliest, often by spring of the same year. Polar expeditions and Galápagos voyages can sell out 12 to 18 months in advance due to limited ship capacity. European Christmas Markets sailings and Hawaii winter departures also book quickly. For most other itineraries, three to six months is a reasonable planning window, though earlier is always better on small ships where cabin counts are limited.