River Cruise Destinations
Discover America's most iconic waterways — from the storied Mississippi River to the majestic rivers of Alaska.
Browse Cruise Destinations
The Last Frontier
Alaska Cruises
Glaciers and the Inside Passage
Salish Sea
British Columbia Cruises
Orcas, Victoria, and Butchart Gardens
Channel Islands
California Coast Cruises
Channel Islands wildlife
Maritime North
Canada Cruises
All five Great Lakes and beyond
Early American History
Chesapeake Bay Cruises
D.C. to Baltimore history
Pacific Northwest
Columbia River Cruises
Gorges, vineyards, and history
Eastern Seaboard
East Coast Cruises
Colonial towns and coastal heritage
Rivers & Coastlines
European Cruises
Danube, Rhine, and the Seine
The Sixth Sea
Great Lakes Small Ship Cruises
Niagara Falls to Mackinac Island
All-Inclusive Islands
Hawaii Small Ship Cruises
All-inclusive island sailing
Fall Foliage
Hudson River Cruise from NYC
NYC to Albany in fall color
Around the World
International Cruises
Caribbean to the Galápagos
New Orleans to Memphis
Lower Mississippi River Cruises
New Orleans to Memphis blues
3,000 Miles of Waterway
Midwest River Cruises
3,000+ miles of waterways
America's Great River
Mississippi River Cruises
New Orleans to Mark Twain country
Harbors, History, Horizons
New England Cruises
Lighthouses to Quebec City
Seafaring History
Northeast USA Cruises
Lighthouses and fall foliage
Bourbon Country
Ohio River Small Ship Cruises
Pittsburgh to bourbon country
Lewis & Clark Country
Pacific Northwest Cruises
Lewis and Clark country
Washington State
Puget Sound Cruises Seattle
Islands, channels, and snow peaks
Atlantic Intracoastal
Southeast US Small Ship Cruises
Savannah to the Florida coast
Music City Country
Tennessee, Cumberland, & Arkansas River Small Ship Cruises
Memphis to Chattanooga music
Mark Twain Country
Upper Mississippi River Cruises
St. Louis to St. Paul bluffs
Coast to Coast
USA Cruises
Coast to coast small ship sailing
Find Your Cruise Destination
USA River Cruises has been putting travelers on the water since 1996, with itineraries ranging from 7-night river voyages in the American heartland to 22-night Mississippi River crossings, wildlife expeditions in the Galápagos and Baja California, polar voyages, European river circuits, and small ship island cruises in Hawaii and the Caribbean.


Domestic Program
The domestic program covers the Mississippi from New Orleans to St. Paul, the Columbia and Snake Rivers, the Ohio River, the Cumberland and Tennessee Rivers, the Hudson River in fall foliage season, the Chesapeake Bay, New England, the Southeast Intracoastal Waterway, the Great Lakes, the Channel Islands, the San Juan Islands and Puget Sound, and the Hawaiian Islands. Internationally, the program reaches the Caribbean, Baja California, Canada’s Atlantic Maritimes, Europe’s Rhine, Danube, and Seine, the Galápagos, Tahiti, Central America, and the polar regions. Browse the destination pages above or call 866-636-2865 and our agents will help you find the right fit.
Frequently Asked Questions
Does USA River Cruises only offer river cruises?
How do I choose between a domestic and an international cruise?
What is the difference between a river cruise and an expedition cruise?
Are these cruises all-inclusive?
How far in advance should I book?