Charmed by the mighty Lower Mississippi River? Our USA River Cruise agents are ready and waiting to help you plan a journey like no other.

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The Lower Mississippi River is filled with diverse, culturally rich regions that promise historical, musical and gustatory experiences unlike those found anywhere else in the world. For this reason, our cruises are customized to suit the experience you are seeking — whatever that may be. Are you a Civil War buff? Do you treasure the writings of Mark Twain. Or do you seek a Mardi Gras full of dance, color and delicious food?

No matter what aspect of this mighty river and its many facets appeals to you, we have the cruise of your dreams.

You’ll enjoy between six and 22 days of fabulous food, music, camaraderie and relaxation, sitting on the deck of one of our gorgeous paddle wheelers. This fantastic mode of travel slows life down and allows you to soak up every ounce of beauty along this iconic body of water.

Our booking agents are ready to answer any questions you may have and to accommodate any and all special needs.

Each member of our staff is uniquely qualified to customize the trip of a lifetime. Most of us have taken these cruises ourselves and are intimately familiar with every detail of the journey, making us the best possible resource for you. Call us! We’re excited to help you launch!

St. Louis to Cincinnati | 9-Day Voyages

St. Louis to Cincinnati

  • 8 Nights
  • April 19, 2020
  • From $2,299
  • American Duchess
  • Save $400 per stateroom on select 2020 departures
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Nashville to St. Louis | 9-Day Voyages

Nashville to St. Louis

  • 8 Nights
  • April 12, 2020
  • From $2,399
  • American Duchess
  • Save $400 per stateroom on select 2020 departures
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Louisville to Nashville | 9-Day Voyages

Louisville to Nashville

  • 8 Nights
  • May 3, 2020,September 13, 2020
  • From $2,699
  • American Duchess
  • Save $400 per stateroom on select 2020 departures
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Memphis to St. Louis | 9-Day Voyages

Memphis to St. Louis

  • 8 Nights
  • September 27, 2020,October 18, 2020
  • From $2,399
  • American Duchess
  • Save $400 per stateroom on select 2020 departures
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Memphis to Louisville | 9-Day Voyages

Memphis to Louisville

  • 8 Nights
  • August 23, 2020
  • From $2,599
  • American Duchess
  • Save $400 per stateroom on select 2020 departures
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Minneapolis to New Orleans | 16-Day Voyages

Minneapolis to New Orleans

  • 15 Nights
  • August 2, 2020
  • From $5,699
  • American Duchess
  • Save $800 per stateroom on select 2020 departures
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Lower Mississippi River Cruise: New Orleans – Memphis

New Orleans to Memphis

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Minneapolis to New Orleans | 16-Day Voyages

Minneapolis to New Orleans

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Memphis to St. Louis | 9-Day Voyages

Memphis to St. Louis

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New Orleans to Memphis | 9-Day Voyages

New Orleans to Memphis

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New Orleans 9-day Mississippi River Cruise

Roundtrip New Orleans

  • 8 Nights
  • February 16, 2020,December 20, 2020,December 27, 2020
  • From $1,899
  • American Queen
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Roundtrip New Orleans | 8-Day Voyages

Roundtrip New Orleans

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