Click Here to learn more about new safety measures related to cruise travel.

Charmed by the mighty Lower Mississippi River? Our USA River Cruise agents are ready and waiting to help you plan a journey like no other.

Read More

The Mississippi River is filled with diverse, culturally rich regions that promise historical, musical, and gustatory experiences unlike those found anywhere else in the world.

For this reason, our cruises are customized to suit the experience you are seeking — whatever that may be.

Are you a Civil War history buff? Do you treasure the writings of Mark Twain? Or do you seek a Mardi Gras full of dance, color, and delicious food?

No matter what aspect of this mighty river and its many facets appeals to you, we have the cruise of your dreams.

With ports of call that span the region — from St. Paul, Minnesota, (for our Upper Mississippi river cruises) to New Orleans, you’ll feel like the king and/or queen of the Mississippi.

Explore from St. Louis to St. Paul — and points both north and south — with USA River Cruises on one of our quintessential American cruise line adventures!

Your Lower Mississippi Itinerary

You’ll enjoy between six and 22 days of fabulous food, music, camaraderie, and relaxation. Sit on the deck of one of our gorgeous paddle wheelers. This fantastic mode of travel slows life down and allows you to soak up every ounce of beauty along this iconic body of water.

Consider just one of our fabulous Mississippi cruises: the New Orleans to Memphis, 8-day voyage.

If you arrive in New Orleans a few days before the cruise launches, you have the opportunity to fully explore and experience the wealth of cultural amenities that abound in the Big Easy, including:

THE GARDEN DISTRICT: A fabulous and historic neighborhood, filled with oak-lined boulevards, grand mansions, and, of course, lush gardens. It’s also the location of the famed Lafayette Cemetery, which is the final resting place of several historical figures, including John Howard Ferguson, who was the defendant in the Supreme Court’s Plessy v. Ferguson decision that established the “separate but equal” doctrine that was later overturned in the 1950s.

THRE FRENCH QUARTER: No trip to New Orleans is complete without at least a walk-through of the famous district. Here you’ll find Bourbon Street — the beating heart of Mardis Gras — and Jackson Square, where ceremonies marking the transfer of the Louisiana Purchase territory from France to the United States took place in 1803.

Once you board our magnificent cruise ships, you’ll get to explore both the history and the modern amenities of the Big Muddy — as the Mississippi is sometimes called. You’ll cruise from New Orleans to Memphis, Tennessee (or the reverse!). It’s Mississippi Delta living at its finest.

Along the way, you’ll visit several more fabulous locations, including Baton Rouge, Louisiana, the state capital and home to Louisiana State University.

You’ll also experience wonderful Natchez, Mississippi, home to indigenous culture stretching back hundreds of years. You can even visit Longwood Plantation, which remains unfinished because workers abandoned it to fight in the Civil War. This is history at its most intimate and immediate.

One last point of interest (among many on your journey): Vicksburg, Mississippi, where you can tour the Vicksburg National Military Park and see for yourself artifacts of early American history, including gunboats and Civil War battlefields.

If you travel upriver, you’ll disembark at Memphis, but there’s a lot more to explore along the Mississippi, including St. Louis, Missouri, just a few hours upriver from Memphis. (Check out our other Mississippi cruises for more info.) If you travel downriver (Memphis to New Orleans), the sights and scenes are just as magical, and the sounds — from blues to bluegrass and rock ‘n’ roll — are as diverse as the scenery.

USA River Cruises: Your Destination Awaits!

Our booking agents are ready to answer any questions you may have and to accommodate any and all special needs.

Each member of our staff is uniquely qualified to customize the trip of a lifetime. Most of us have taken these cruises ourselves and are intimately familiar with every detail of the journey, making us the best possible resource for you.

Call us! We’re excited to help you launch your Mississippi River cruise!

Memphis to St. Louis | American Culinary Experience

Memphis to St. Louis

  • 8 Nights
  • October 3, 2021,June 11, 2022,July 16, 2022
  • From $2,099
  • American Duchess
Book Now More Info

Memphis to Louisville | 9-Day Voyages

Memphis to Louisville

Book Now More Info

Minneapolis to New Orleans | 16-Day Voyages

Minneapolis to New Orleans

Book Now More Info

Lower Mississippi River Cruise: New Orleans – Memphis

New Orleans to Memphis

Book Now More Info

New Orleans 9-day Mississippi River Cruise

Roundtrip New Orleans

  • 8 Nights
  • December 26, 2021,February 13, 2022,December 25, 2022
  • From $1,999
  • American Queen
Book Now More Info

Memphis to St. Louis | 8-Day Voyages

Memphis to St. Louis

Book Now More Info

The Mighty Mississippi | 15-Day Voyage

Minneapolis to New Orleans

Book Now More Info

New Orleans to Memphis | 9-Day Voyages

New Orleans to Memphis

Book Now More Info

The Gateways of the Mississippi: New Orleans to St. Louis

New Orleans to St. Louis

Book Now More Info

Mississippi River Cruise – Queen of Mississippi

Roundtrip New Orleans

Book Now More Info

Cruises out of New Orleans

Roundtrip New Orleans

Book Now More Info

The Mighty Mississippi | 16-Day Voyage

Minneapolis to New Orleans

  • 15 Nights
  • July 25, 2021,September 11, 2022
  • From $4,599
  • American Queen
Book Now More Info
logo-white