The Gateways of the Mississippi: New Orleans to St. Louis

This unique itinerary on the Lower Mississippi takes you from the ‘Gateway to the West’ in St. Louis to New Orleans – our original ‘Gateway’ to the Mississippi and America’s Heartland!

You’ll start your journey in New Orleans, see Baton Rouge, Natchez, Vicksburg and its Civil War connection, Memphis, New Madrid, the Trail of Tears Park, Paducah, and St. Louis

Cruise Details

Clock12 Days & 11 Nights

Double Occupancy from $6,245 pp/do*

Single Occupancyfrom $8,215 pp

CalendarJuly 2, 2024 | September 6, 2024 | July 1, 2025

Book Now Request More Info

or call 800.578.1479

*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

    1Embark in New Orleans, LA
    Welcome aboard the Queen of the Mississippi!

    2Cruising the Mississippi River
    Board your ship and be treated to a welcome reception. Get to know your fellow travelers and savor the view as you enjoy the afternoon cruising the mighty Mississippi River.

    3Baton Rouge, LA
    Meaning “red stick,” Baton Rouge’s 1699 French name references an ancient geographical marker and reflects the city’s long history. As Louisiana’s state capital, the city still echoes with tales of the characters who lived here, most notably Governor and Senator Huey P. Long. Learn about his dramatic career at the magnificent 1852 Old State Capitol Museum and visit Long’s 1932 State Capitol building, an architectural marvel of granite and marble

    4Natchez, MS
    Enjoy a private city tour with a local expert guide who can point out the influences of different groups of people who have left their mark in Natchez, from the indigenous Native American to the European and African cultures. Other optional activities for today include a tour of the Frogmore Plantation where you’ll be able to pick cotton from the fields and witness the technology that creates 900 bales per day.

    5Vicksburg, MS
    You cannot visit Vicksburg without touring the Battle of Vicksburg location, now a National Military Park. You’ll see the restored gunboat, the USS Cairo, as well as walk the battlefield of the Siege of Vicksburg.

    6River Cruising
    Relax on board today, don't miss onboard presentations and cocktail hour!

    7Memphis, TN
    Visit historic Beale Street to hear the beat of ‘Blues City’ or head over to Graceland to pay tribute to the King of Rock and Roll, Elvis Presley!

    8New Madrid, MO
    Founded in 1776, original settlers of New Madrid were required to become official citizens of Spain. A number of Americans settled there. In a three year period, the territory was traded to France and then sold to the United States. Today, the two remains committed to remembering its history, with sites including the Trail of Tears Park and the Kochtitsky Home.

    9Paducah, KY
    Where rivers come together, so do people. At the confluence of the Ohio and Tennessee Rivers, you’ll find the building of history quite tangible. Walk through Paducah and remember the Chicasaw village which preceded the town. View the history through the Wall-to-Wall mural collection of more than 50 murals.

    10River Cruising
    Sit up on the sun deck and watch the scenery as you float by.

    11St. Louis, MO
    Parked on the riverfront, you’ll have the best view of the Gateway Arch! Ride the arch to the top (630 feet) to get the best view of the city and the river. You can also visit the Museum of Westward Expansion to learn about the people who created the nation we live in now: the explorers, cowboys and Native Americans. Other popular destinations in St. Louis include: the Anheuser Busch Brewery, home of the Clydesdale horses; a driving tour of the 1371 acre Forest Park in the city; the art museum, science center and so much more. Check the MLB schedule to see if you can fit in a Cardinals game!

    12Disembark in St. Louis, MO
    After breakfast, transfer to the airport or extend your stay with a hotel package.


Cabin Categories

Cabin Single Price Double Price
Owner's Suite (Private Balcony)$11,085 pp
AAM (Private Balcony)$8,380 pp
AAC (Private Balcony)$7,880 pp
AAL (Private Balcony)$7,595 pp
AAR (Private Balcony)$7,160 pp
A$6,245 pp
Single (Private Balcony)$9,080

Ship Read more about the American Heritage

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

Book Today

The Gateways of the Mississippi: New Orleans to St. Louis

Book Now Request More Info

or call 800.578.1479