The Ohio River rolls and roils along, from Pittsburgh, Pennsylvania, to Cairo, Illinois. It’s the largest tributary by volume of the Mississippi River.

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In fact, at its confluence with the Mississippi, the Ohio (Seneca for “good river”) is considerably more mighty than the mighty Mississippi itself!

How mighty? Consider: The Ohio River is 981 miles long, flows through or borders six states, and is home to more than 25 million people — about 10 percent of the U.S. population (in the Ohio River basin).

USA River Cruises provides opportunities for the adventure seeker and the amateur (or not so amateur) historian aboard one of our Ohio River cruises.

For example, we offer an eight-day trip from lovely little Alton, Illinois (actually on the Mississippi River not far from St. Louis, Missouri), to Louisville, Kentucky. The trip begins on a high note in Alton, site of the last debate between Abraham Lincoln and Stephen Douglas in October 1858.

Many of our trips provide convenient dry-land travel on board our “Hop-On/Hop-Off” buses. These buses (which look just like our ships!) travel alongside our cruises from port to port, so you’ll be able to take exciting shore excursions without the hassle of worrying about ground transport.

Call USA River Cruises now for details!

Louisville to Nashville | 9-Day Voyages

Louisville to Nashville

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Music Cities Cruise

Memphis, TN to Nashville, TN

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Memphis to Louisville | 9-Day Voyages

Memphis to Louisville

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Cincinnati to Louisville | Kentucky Derby

Louisville to Cincinnati

  • 8 Nights
  • May 1, 2023
  • From $3,399
  • American Countess
  • Join the one Kentucky Derby Departure for 2023!!
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Louisville to Pittsburgh | 9-Day Voyages

Louisville to Pittsburgh

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Ohio River Cruise: St. Louis to Pittsburgh

St. Louis to Pittsburgh

  • 10 Nights
  • August 5, 2023,August 15, 2023,August 25, 2023
  • From $5,415
  • American Heritage
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