Ohio River Cruise: St. Louis to Pittsburgh

Time to cruise east, leaving the familiar Mississippi behind for the Ohio River! Follow the history of the pioneers who kept pushing the boundaries of American identity in music, culture, architecture, and more. From St. Louis to Pittsburgh (or reverse), this Ohio River cruise will introduce you to the heartland of America. From the start of the cruise in St. Louis, you’ll pick up the rhythm of the river. The Queen of the Mississippi will continue that rhythm with the churning paddlewheel and joyful noise of the calliope! Journeying southeast, you’ll visit Paducah, where the Tennessee and Ohio Rivers come together. Where waters meet, so do people, making Paducah rich in history. Walk among the bronze ‘Birds of America’ statues in Henderson, based on the paintings of John James Audubon. Feel the spirit of the South alive in the northern Louisville. Walk through history along the river’s edge. Continue your 11-Day cruise northeast through ports of call in Ohio and Kentucky before disembarking in Pittsburgh, Pennsylvania.


Pittsburgh | Marietta | Maysville | Cincinnati | Louisville | Henderson | Paducah | Cape Girardeau | St. Louis

Cruise Details

Clock11 Days & 10 Nights

Double Occupancy from $5,685 pp/do*

Single Occupancyfrom $7,385 pp

CalendarJuly 11, 2023 | July 21, 2023 | July 31, 2023 | August 10, 2023 | August 20, 2023 | August 30, 2023
See 2 more available dates
September 9, 2023 | September 19, 2023

Book Now Request More Info

or call 800.578.1479

*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

    1Embark in Pittsburgh, PA
    Welcome aboard the Queen of the Mississippi! This itinerary includes a complimentary pre-cruise hotel stay in Pittsburgh!

    2Marietta, OH
    Named for Marie Antoinette, Marietta shares a metropolitan area with Parkersburg and Vienna, West Virginia, with their location on the Ohio River making it a continually popular stop for tourists and steamboats.

    3Maysville, KY
    Maysville is a quaint town, surrounded by picturesque scenery with the sounds of bluegrass music on the wind!

    4Cincinnati, OH
    Cincinnati is a fascinating city, full of highlights to excite everyone. If you’re interested in history, you could visit the William Howard Taft National Historic Museum, or the National Underground Railroad Freedom Center. If you’d rather experience natural wonders, take a tour of the Krohn Conservatory – an art deco building built in 1933 with more than 5000 varieties of plants from around the world. If you’re not sure what you want to see, start your day with the complimentary city tour to get a better understanding of the layout of Cincinnati, and an idea of where to go next.

    5Louisville, KY
    Louisville – pronounced differently depending on where you’re from, but named for King Louis XVI of France and famously home to the Kentucky Derby! Louisville is home to the Louisville Slugger Museum and Factory, or you could visit nearby Clermont to tour the Jim Beam bourbon distillery.

    6Louisville, KY
    Take an excursion to the Kentucky Derby Museum and Horse Park, which has footage dating as far back as 1918.

    7Henderson, KY
    Notable Henderson resident, John James Audubon, has left a legacy of nature in town. His ‘Birds of America’ paintings have been recreated in bronze throughout town. The Audubon Museum Tour is complimentary on this cruise.

    8Paducah, KY
    Where rivers come together, so do people. At the confluence of the Ohio and Tennessee Rivers, you’ll find the building of history quite tangible. Walk through Paducah and remember the Chicasaw village which preceded the town. View the history through the Wall-to-Wall mural collection of more than 50 murals.

    9Cape Girardeau, MO
    History abounds in this charming river town. Once a popular French trading post, the town’s historic standing is on full display. Visit Civil War sites, the Cape River Heritage Museum, the Red House Interpretive Center, or the commemorative Trail of Tears State Park.

    10St. Louis, MO
    There's a complimentary excursion today; The Discover St. Louis Tour!

    11Disembark in St. Louis, MO
    After breakfast, transfer to the airport or extend your stay with a hotel package.


Cabin Categories

Cabin Single Price Double Price
Owner's Suite$9,995 pp
AAM (Private Balcony)$7,825 pp
AAC (Private Balcony)$7,360 pp
AAL (Private Balcony)$6,940 pp
AAR (Private Balcony)$6,390 pp
A$5,685 pp
Single (Private Balcony)$8,105

Ship Read more about the American Heritage

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

Book Today

Ohio River Cruise: St. Louis to Pittsburgh

Book Now Request More Info

or call 800.578.1479