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Thinking about hopping aboard a USA River Cruise to explore the Upper Mississippi? Then you’ve got a lot to look forward to — and a little planning to do.

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But don’t worry. It’s the fun kind of planning. The kind when you choose from a tremendous variety of Mississippi River cruises and pick the one that best suits your tastes and interests.

USA River Cruises has so many cruises along the Upper Mississippi River that we sometimes have a hard time confining them to one page of our website!

What’s on your itinerary? Let’s look at just a few — and we’d like to stress again just how many options there are!

The first trip we’ll mention really puts the Upper in Upper Mississippi — an eight days, seven nights cruise from St. Louis, Missouri, to Minneapolis, Minnesota.

The Upper Mississippi River is stunning, inspirational, and for many people the more scenic half of the waterway. You’ll explore the world where the former Samuel Clemens (pen name: Mark Twain) grew up. Twain, raised in Hannibal, Missouri, actually worked for a time as a riverboat pilot on the mighty Mississippi. You’ll also get to see much of the American heartland, including Dubuque, Iowa, La Crosse, Wisconsin, and Red Wing, Minnesota.

And if you’re interested in the trip downriver instead of up, well, USA River Cruise can reverse this itinerary for you, too!

Next, consider expanding your trip to encompass the whole shebang: We call it the Complete Mississippi River Cruise, and the name is apt.

You’ll spend a full three weeks aboard ship as you cruise the length of the second-longest river in North America — from New Orleans, Louisiana, to St. Paul, Minnesota. You’ll visit big towns (Memphis, St. Louis, and more) and small towns (Vicksburg, Mississippi, and Chester, Illinois, where you can get a picture of a tall bronze statue of Popeye, whose creator, E. C. Segar, is from Chester).

You’ll have to act fast for this one, though. USA River Cruises only offers this trip once per year!

Call today!

Memphis to Chicago

Memphis to Chicago

  • 8 Nights
  • September 18, 2021,September 25, 2021
  • From $2,299
  • American Countess
  • Save up to $600 off per Stateroom on Select Cabins and select 2021 Departures!!
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Viking America’s Great River

St Paul to New Orleans

  • 14 Nights
  • September 17, 2022,October 1, 2022,October 15, 2022
  • From $9,899
  • Viking Mississippi
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Viking America’s Heartland

St Louis to St Paul

  • 7 Nights
  • August 27, 2022,September 3, 2022,September 10, 2022
  • From $4,899
  • Viking Mississippi
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St. Louis to Cincinnati | 9-Day Voyages

St. Louis to Cincinnati

  • 8 Nights
  • April 18, 2021
  • From $1,999
  • American Duchess
  • Save up to $1000 per stateroom on select 2021 departures and cabins!
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Nashville to St. Louis | 9-Day Voyages

Nashville to St. Louis

  • 8 Nights
  • April 11, 2021
  • From $2,099
  • American Duchess
  • Save up to $1000 per stateroom on select 2021 departures and cabins!
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Minneapolis to New Orleans | 16-Day Voyages

Minneapolis to New Orleans

  • 15 Nights
  • August 2, 2020,August 1, 2021
  • From $4,999
  • American Duchess
  • Save up to $1200 per stateroom on select 2021 departures and cabins!
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Minneapolis to New Orleans | 16-Day Voyages

Minneapolis to New Orleans

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St. Louis to Minneapolis | 9-Day Voyages

St. Louis to Minneapolis

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St. Louis to Minneapolis | 8-Day Voyages

St. Louis to Minneapolis

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The Mighty Mississippi | 15-Day Voyage

Minneapolis to New Orleans

  • 14 Nights
  • September 20, 2020,August 28, 2021
  • From $4,399
  • American Countess
  • Save up to $1200 per stateroom on select 2021 departures and cabins!
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Upper Mississippi River Cruise: St. Louis – St.Paul

St. Louis to St. Paul

  • 7 Nights
  • August 28, 2020,September 4, 2020,September 11, 2020
  • From $4,515
  • American Harmony
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Complete Mississippi River Cruise

New Orleans to St. Paul

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