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Thinking about hopping aboard a USA River Cruise to explore the Upper Mississippi? Then you’ve got a lot to look forward to — and a little planning to do.

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But don’t worry. It’s the fun kind of planning. The kind when you choose from a tremendous variety of Mississippi River cruises and pick the one that best suits your tastes and interests.

USA River Cruises has so many cruises along the Upper Mississippi River that we sometimes have a hard time confining them to one page of our website!

What’s on your itinerary? Let’s look at just a few — and we’d like to stress again just how many options there are!

The first trip we’ll mention really puts the Upper in Upper Mississippi — an eight days, seven nights cruise from St. Louis, Missouri, to Minneapolis, Minnesota.

The Upper Mississippi River is stunning, inspirational, and for many people the more scenic half of the waterway. You’ll explore the world where the former Samuel Clemens (pen name: Mark Twain) grew up. Twain, raised in Hannibal, Missouri, actually worked for a time as a riverboat pilot on the mighty Mississippi. You’ll also get to see much of the American heartland, including Dubuque, Iowa, La Crosse, Wisconsin, and Red Wing, Minnesota.

And if you’re interested in the trip downriver instead of up, well, USA River Cruise can reverse this itinerary for you, too!

Next, consider expanding your trip to encompass the whole shebang: We call it the Complete Mississippi River Cruise, and the name is apt.

You’ll spend a full three weeks aboard ship as you cruise the length of the second-longest river in North America — from New Orleans, Louisiana, to St. Paul, Minnesota. You’ll visit big towns (Memphis, St. Louis, and more) and small towns (Vicksburg, Mississippi, and Chester, Illinois, where you can get a picture of a tall bronze statue of Popeye, whose creator, E. C. Segar, is from Chester).

You’ll have to act fast for this one, though. USA River Cruises only offers this trip once per year!

Call today!

Journey Along the Upper Mississippi | Rail & Sail

Chicago to St. Paul, MN

  • 9 Nights
  • July 17, 2021,August 20, 2021
  • From $3,051
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Memphis to Chicago

Memphis to Chicago

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Viking America’s Great River

St Paul to New Orleans

  • 14 Nights
  • September 17, 2022,October 1, 2022,October 15, 2022
  • From $9,899
  • Viking Mississippi
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Viking America’s Heartland

St Louis to St Paul

  • 7 Nights
  • August 27, 2022,September 3, 2022,September 10, 2022
  • From $4,899
  • Viking Mississippi
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St. Louis to Cincinnati | 9-Day Voyages

St. Louis to Cincinnati

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Nashville to St. Louis | 9-Day Voyages

Nashville to St. Louis

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Minneapolis to New Orleans | 16-Day Voyages

Minneapolis to New Orleans

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St. Louis to Minneapolis | 9-Day Voyages

St. Louis to Minneapolis

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St. Louis to Minneapolis | 8-Day Voyages

St. Louis to Minneapolis

  • 7 Nights
  • August 21, 2021,October 2, 2021,October 9, 2021
  • From $2,599
  • American Countess
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The Mighty Mississippi | 15-Day Voyage

Minneapolis to New Orleans

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Roundtrip Minneapolis | 9-Day Voyages

Roundtrip Minneapolis

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St. Louis to Minneapolis | 9-Day Voyages

St. Louis to Minneapolis

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