Upper Mississippi River Cruise: St. Louis – St.Paul

The Upper Mississippi River is prime location to discuss one of the greatest American authors and commentators in our history: Mark Twain! Not only will you be cruising the river he loved so dearly, you’ll be able to visit the important Tom Sawyer town of Hannibal. The boyhood home of Samuel Clemens (Mark Twain), Hannibal is a great small river town for you to explore. Visit the actual home he grew up in, surrounded by the whitewashed fence. You can also visit Becky Hatcher’s home and Huck Finn’s home, and take your picture with the Tom and Huck Statue on Cardiff Hill.

Ports of Call: St. Louis | Hannibal | Fort Madison | Davenport | Dubuque | Winona | Red Wing | St. Paul

Cruise Details

Clock9 Days & 8 Nights

Double Occupancy from $5,545 pp/do*

Single Occupancyfrom $7,035 pp

CalendarJuly 9, 2024 | July 16, 2024 | July 23, 2024 | July 30, 2024 | August 6, 2024 | August 13, 2024
See 4 more available dates
August 20, 2024 | August 27, 2024 | September 3, 2024 | September 10, 2024

Book Now Request More Info

or call 800.578.1479

*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

    1St. Louis, MO/Alton, IL
    Welcome aboard the American Melody! We will transfer our guests from their pre-night hotel in St. Louis to Alton where we will board.

    2Cruising the Mississippi River
    Curl up with a good book in one of our spacious lounges aboard the riverboat. Or relax on the sun deck or private balcony and enjoy the passing landscapes as we make our way along the Mississippi River.

    3Hannibal, MO
    Kick off your Mark Twain Tribute cruise in his boyhood hometown of Hannibal. Be sure to also visit the Interpretive Center, which houses 15 original Normal Rockwell paintings!

    4Day of River Cruising
    Kick back and relax as you move onto Muscatine!

    5Muscatine, IA
    Located in East Central Iowa, Muscatine County's eastern edge touches the banks of the Mighty Mississippi River and is the only place where this north to south river runs east to west. Perhaps Muscatine is best known for its history as the largest button manufacturing area in the world. Learn about this idyllic town’s rich past and revel in its natural beauty, led by our engaging local guides. Explore the charming downtown, located only two blocks from our dock, where you peruse local boutiques, coffee shops, and eateries.

    6Dubuque, IA
    One of the oldest settlements west of the Mississippi, Dubuque is a fascinating town full of just about everything. The complimentary shore excursion includes a historic city tour. Dubuque has Victorian era attractions, and you’ll learn about the history of this beautiful town with stops at Mathias Ham House and the Old Jail Museum.

    7Winona, MN
    Step into 19th-century America in Winona! Located in the picturesque bluff country on the Mississippi River. Explore this vibrant small town with the perfect blend of urban edge and old world charm.

    8Red Wing, MN
    Red Wing is a fantastic river town with much to explore. Take a bald eagle viewing cruise with Captain Rusty. Or tour the town on the Red Wing Trolley to visit local shops, art galleries, and antique stores. Or tour the Red Wing Pottery workshop, where they’ve been producing stoneware for three generations.

    9Disembark in St. Paul, MN
    After breakfast, transfer to the airport or extend your stay with a hotel package.


Cabin Categories

Cabin Single Price Double Price
Grand Suite (Private Balcony)$10,530 pp
Veranda Suite (Private Balcony)$7,655 pp
AAM (Private Balcony)$6,530 pp
AAC (Private Balcony)$6,105 pp
AAR (Private Balcony)$5,545 pp
Single (Private Balcony)$7,035

Ship Read more about the American Serenade

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

Book Today

Upper Mississippi River Cruise: St. Louis – St.Paul

Book Now Request More Info

or call 800.578.1479