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Mississippi River Cruises

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ALL 2017 MISSISSIPPI RIVER CRUISES INCLUDE A 1-NIGHT PRE-CRUISE HOTEL!

The Mighty Mississippi Awaits!

Charmed by the mighty Mississippi River? Our USA River Cruise agents are ready and waiting to help you plan a journey like no other.

The Mississippi River is filled with diverse, culturally-rich regions that promise historical, musical, and gustatory experiences unlike those found anywhere else in the world. For this reason, our cruises are customized to suit the experience you are seeking, whatever that may be. Are you a Civil War buff? Do you treasure the writings of Mark Twain, or love to dance the night away to Louis Armstrong’s jazz classics? Or are you seeking a Mardi Gras full of dance, color, and delicious food?

No matter what aspect of this mighty river and its many facets appeals to you, we have the cruise of your dreams. You’ll enjoy six to 22 days of fabulous food, music, comradery, and relaxation, sitting on the deck of one of our gorgeous paddle wheelers. This fantastic mode of travel slows life down and allows you to soak up every ounce of beauty along this iconic body of water.

Our booking agents are ready to answer any questions you may have and to accommodate any and all special needs. All of our staff are uniquely qualified to customize the trip of a lifetime. Most of us have taken these cruises ourselves and are intimately familiar with every detail of the journey, making us the best possible resource for you. Call us; we’re excited to help you launch!

Cumberland River Cruise: Nashville – St. Louis

Save up to $2500 Off Per Stateroom on Select 2017 Departures!!
Book by: 05/27/2017

The Cumberland River is a historic route of music, cuisine, and love of all things Southern. Cruise along the River on the Queen of the Mississippi paddlewheel, relaxing perhaps in the Sky Lounge- More...

Upper Mississippi River Cruise: St. Louis – St.Paul

Save up to $1300 Off Per Stateroom on Select 2017 Departures!
Book by: 05/27/2017

Two magnificent paddlewheelers are cruising the Upper Mississippi River: the Queen of the Mississippi and the America (new to the river 2016). Escape the heat of Summer with the cool breezes from the- More...

Grand Heartland Cruise

Book 9 Months in Advance and Save up to $400 off on 2017 Departures!!
Book by: 05/31/2017

Time to Check 'Mississippi River' Off Your Bucket List! Are you ready to cruise the entire length of the Mississippi River? You may have cruised segments before, but nothing can compare to- More...

Complete Mississippi River Cruise

Save up to $2500 Off Per Stateroom on Select Departures!!
Book by: 05/27/2017

Enjoy a complete Mississippi River cruise!- More...

Cruise the Deep South: New Orleans, Round Trip

Save up to $1000 Off Per Stateroom on Select 2017 Departures!!
Book by: 05/27/2017

New Orleans is situated at the mouth of the Mississippi River, guardian of the treasures that abound along the river's edge. Let the America or the Queen of the Mississippi be your river guide,- More...

Lower Mississippi River Cruise: New Orleans – Memphis

Save up to $1500 Off Per Stateroom on Select 2017 Departures!!
Book by: 05/27/2017

Explore historic and modern river life on this unique exploration of the Lower Mississippi River. Cruising from NOLA to Memphis, or reverse, you'll catch the heartbeat of the river. Enjoy Cajun- More...

The Gateways of the Mississippi: New Orleans to St. Louis

Save up to $2500 Off Per Stateroom on Select 2017 Departures!!
Book by: 05/27/2017

This unique itinerary on the Lower Mississippi takes you from the 'Gateway to the West' in St. Louis to New Orleans - our original 'Gateway' to the Mississippi and America's Heartland! Most of- More...

Ohio River Cruise: St. Louis to Pittsburgh

Save up to $2500 Off Per Stateroom on Select 2017 Departures!!
Book by: 05/27/2017

Time to cruise east, leaving the familiar Mississippi behind for the Ohio River! Follow the history of the pioneers who kept pushing the boundaries of American identity in music, culture,- More...

Roundtrip Louisville | 9-Day Voyages

Save up to $800 per stateroom
Book by: 05/31/2017

ONLY DEPARTURE: JULY 9, 2017! This itinerary cruising roundtrip from Louisville is only offered once in 2017, and not scheduled at all in 2018. To celebrate this cruise, the Chairman of the American- More...

Cincinnati to Memphis | 9-Day Voyages

Save $600 per stateroom when you pay in full
Book by: 07/30/2017

Cruise along the Ohio River towards the mighty Mississippi. This cruise is uniquely planned to highlight the region's history and passion for making bourbon - America's Native Spirit. Journey through- More...

St. Louis to Chicago | 9-Day Voyages

St. Louis to Chicago | 9-Day Voyages

It's the Land of Lincoln. Whether you choose to cruise north or southbound, the cruise is one-time only. Plan ahead for 2018 by booking this rare cruise route on the Illinois River. 2018- More...

The Mighty Mississippi

The Mighty Mississippi

The American Queen has an opportunity that will allow you to cruise the entire length of the Mighty Mississippi River! Total cruise length is 23-days, including a 1-night pre-cruise hotel in the- More...

Roundtrip New Orleans | 5-Day Voyages

Roundtrip New Orleans | 5-Day Voyages

Short trips on the Mississippi are great when you don't have a long vacation, or as a building block into a longer vacation! These 5 and 6-day trips are just like dipping your toes into the vast sea- More...

Roundtrip New Orleans | 9-Day Voyages

Roundtrip New Orleans | 9-Day Voyages

Allow the charms of the Deep South to come alive as you experience the history and luxury of the region onboard your opulent paddlewheels and in the small river towns along the way. Whether you- More...

Memphis to Louisville | 9-Day Voyages

Memphis to Louisville | 9-Day Voyages

Just once a year, the American Queen and American Duchess will cruise from Memphis to Louisville. Cruising along the Mississippi and Ohio Rivers, you'll enjoy natural wonders like the John James- More...

Louisville to St. Louis | 9-Day Voyages

Louisville to St. Louis | 9-Day Voyages

The American Queen wanders the rivers. On this cruise, it'll amble down the Ohio, dawdle awhile in the Four-Rivers Area (where the Ohio, Tennessee and Cumberland Rivers flow together into the- More...

New Orleans to Memphis | 8 and 9-Day Voyages

New Orleans to Memphis | 8 and 9-Day Voyages

The most popular route on the Mississippi - and therefore the one with the most departures - is the lower Mississippi River from New Orleans to Memphis, or reverse. When you think of river cruising,- More...

Louisville to Cincinnati | 9-Day Voyages

Louisville to Cincinnati | 9-Day Voyages

This cruise route is rare, and to pair it with the legendary Kentucky Derby is unique! This itinerary stays very close to Louisville for the local festivities before heading east to Cincinnati. Aside- More...

Memphis to Nashville | 8 and 9-Day Voyages

Memphis to Nashville | 8 and 9-Day Voyages

You couldn't cruise to Memphis or Nashville without some reference to the amazing legacy of music that comes from these cities. But to visit both means your cruise will be a week of rhythm and- More...

St. Louis to Minneapolis | 9-Day Voyages

St. Louis to Minneapolis | 9-Day Voyages

The paddlewheels on the Mississippi only head North at the end of Summer, as the region warms up and becomes a more comfortable temperature for cruisers. But once the waters are ready, the ships have- More...

Roundtrip Minneapolis | 9-Day Voyages

Roundtrip Minneapolis | 9-Day Voyages

Only in late Summer does the American Queen venture North to Minneapolis, docking in nearby Red Wing. Take advantage of this by doing the Roundtrip Minneapolis cruise, a rare week of in-depth- More...

Nashville to Chattanooga | 9-Day Voyages

Nashville to Chattanooga | 9-Day Voyages

Venture deeper into Tennessee on this unique cruise. This is steamboat country, because here, the river has always meant life. The river is transportation of people; its the moving of needed supplies- More...

St. Louis to Memphis | 9-Day Voyages

St. Louis to Memphis | 9-Day Voyages

This central Mississippi River cruise is rare - only offered once a year. But staying centrally located means venturing down the Ohio, Tennessee and Cumberland Rivers as well! At each stop, you'll- More...

Roundtrip Nashville | 7, 8 and 9-Day Voyages

Roundtrip Nashville | 7, 8 and 9-Day Voyages

Ready to celebrate a classic country holiday? Book your roundtrip Nashville cruise and celebrate the holiday season with good music, good food and good friends! 2017 American Duchess- More...

Louisville to Pittsburgh | 9-Day Voyages

Louisville to Pittsburgh | 9-Day Voyages

It's rare for a river cruise to venture this far on the Ohio River, but just once in 2018, the American Queen will cruise all the way to Pennsylvania! Learn about Mothman, who haunts Point Pleasant,- More...