Mississippi River Gateway Cruise: New Orleans to Louisville, KY

This unique itinerary on the Lower Mississippi takes you from the ‘Gateway to the West’ in St. Louis to New Orleans – our original ‘Gateway’ to the Mississippi and America’s Heartland!

Cruise Details

Clock12 Days & 11 Nights

Double Occupancy from $6,360 pp/do*

Single Occupancyfrom $8,360 pp

CalendarJuly 8, 2025 | June 23, 2026

Book Now Request More Info

or call 800.578.1479

*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

    1New Orleans, LA
    Welcome to New Orleans, world-renowned for its round-the-clock nightlife, vibrant live-music scene, and unique cuisine reflecting its history as a melting pot of French, African and American influences. This vivacious city is the perfect destination to begin your Mississippi River experience. Settle into your hotel and enjoy the city at your leisure.

    2Cruising the Mississippi River
    Board your ship and be treated to a Welcome Reception. Get to know your fellow guests and savor the view as you enjoy the afternoon rolling on the mighty Mississippi.

    3Oak Alley, LA / Houmas House, LA
    This iconic Southern estate is renowned for its oak-lined avenue, stretching majestically towards the Mississippi River. Built in the early 19th century, this Greek Revival mansion exudes charm with its grand architecture and lush gardens. Visitors are transported back in time as they explore the meticulously preserved interiors and learn about the land’s history, including its role in the sugar industry. Houmas House and Gardens offers a glimpse into the opulent lifestyle of Louisiana's plantation owners. Known as the "Crown Jewel of Louisiana's River Road," this magnificent estate features stunning architecture, lush gardens, and luxurious interiors. Visitors can tour the lavishly decorated rooms, stroll through the expansive grounds, and enjoy fine dining at the onsite restaurant. Houmas House invites guests to step into a world of Southern splendor and hospitality.

    4Day of River Cruising
    Today is your day to unwind and take it all in. Glide effortlessly along the Mighty Mississippi, surrounded by breathtaking panoramas of cottonwood trees and graceful blue herons. Engage in captivating enrichment sessions and lively onboard events. Delight in gourmet cuisine and refreshing cocktails. Whether you're lounging in our spacious lounges or basking in the sun on the deck, there's endless fun to be had. As Mark Twain famously said, it's a day with "nothing to hang a worry or a fret upon" – so let go and embrace the adventure!

    5Vicksburg, MS
    Vicksburg is a place of drama. During the Civil War, the struggle to control Vicksburg proved to be a major turning point. The well-fortified connection between river and rail transportation was known as “The Gibraltar of the West.” A narrated exploration of the well-preserved National Military Park battlefield enlivens this powerful story and highlights its significance. President Abraham Lincoln summarized Vicksburg’s importance clearly when he said, “Vicksburg is the key. The war can never be brought to a close until that key is in our pocket… They can defy us from Vicksburg… As valuable as New Orleans will be to us, Vicksburg will be more so.” Several other excursion options are available, including exploring museums and historic sites with local expert guides or on your own. Walk aboard an enormous Army Corps of Engineers towboat. Stroll along the charming series of murals painted along the adjacent floodwall and read panels detailing the Vicksburg stories they illustrate.

    6Day of River Cruising
    As we make our way from historic New Orleans to St. Louis, revel in the sights and sounds of the spectacular Mississippi River. Spend time chatting with other guests in the lounges or enjoy a cocktail on your private balcony.

    7Memphis, TN
    Welcome to Memphis, a historic city which rises picturesquely up the hillside from the river, adorned with grand oak trees, lush parks, and historic sites that commemorate everything from the Civil War to the Civil Rights Movement. Immerse yourself in its rich musical legacy as you stroll along legendary Beale Street, where music flows from every doorway, and savor the rich flavors and aromas of the city’s famous BBQ. Choose from an array of customized excursions. Perhaps take a narrated motorcoach excursion to get an overview of this dramatic city. Or indulge in the glamour of the Peabody Hotel. Explore the home, life, and career of Elvis Presley or make your pilgrimage to Sun Studio, where he recorded his earliest smash-hits.

    8Day of Cruising
    prev Day 8 - Day of Cruising Today, let's celebrate the journey as much as the destinations themselves. Embrace picturesque landscapes along the iconic Mississippi River. Take pleasure in the unspoiled stretches of land, the quaint charm of riverside towns, and the majestic presence of wildlife. As we glide along the river's gentle currents, take in the expert commentary from our onboard naturalist, who will regale you with tales of the native wildlife that call this region home. Alternatively, find solace in simply basking in the warmth of the sun on the bow, allowing the soothing rhythm of the river to lull you into a state of serene contentment.

    9Paducah, KY
    Residing at the confluence of the Tennessee River and the Ohio River, Paducah will make you feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah’s rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library. Led by our expert guide, tour this enchanting city with a stop National Quilt Museum.

    10Day of River Cruising
    Sit back and enjoy the gentle sounds of the paddlewheel as it churns the placid waters of the Ohio River. One of the highlights of this cruise is the chance to watch the ever-changing scenery as it passes by and experience the river, as early explorers did centuries ago.

    11Louisville, KY
    An impressive waterfront town arching up the hillside, Louisville has a long history of commerce and revelry. The town grew at a portage around the treacherous Falls of the Ohio, now inundated behind the Ohio River’s Markland Dam. The historic importance of river commerce to the town is represented by the “Belle of Louisville” day excursion boat just down the banks, still operating after more than a century. Explore the impressive Churchill Downs to learn about the city’s renowned Kentucky Derby, the oldest continuously held horse race in the country. Or stop by the Louisville Slugger Museum & Factory to see how the famous baseball bats are made. A visit to the a local distillery will lift your spirits as you savor samples and learn about the history of Kentucky bourbons.

    12Louisville, KY
    On your travels back home, reflect on your wonderful memories.

nola-stl_700x1100

Cabin Categories

Cabin Single Price Double Price
Veranda Suite (VS)$10,005 pp
Premium Balcony (PB)$8,445 pp
Deluxe Balcony 1 (DB1)$8,010 pp
Deluxe Balcony 2 (DB2)$7,570 pp
Standard Balcony (SB1)$7,275 pp
Standard Waterview (SW)$6,360 pp
Single Balcony (SGB)$9,245
Single Waterview (SGW)$8,360

Ship Read more about the American Heritage

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

Book Today

Mississippi River Gateway Cruise: New Orleans to Louisville, KY

Book Now Request More Info

or call 800.578.1479

logo-white