Mississippi River Gateway Cruise: New Orleans to St. Louis

This unique itinerary on the Lower Mississippi takes you from the ‘Gateway to the West’ in St. Louis to New Orleans – our original ‘Gateway’ to the Mississippi and America’s Heartland!

Cruise Details

Clock12 Days & 11 Nights

Double Occupancy from $6,245 pp/do*

Single Occupancyfrom $8,215 pp

CalendarJuly 3, 2024 | September 7, 2024

Book Now Request More Info

or call 800.578.1479

*Per person/double occupancy. Special single rates apply where listed. Excludes port fees.
Itineraries may operate in reverse.

Your Itinerary

    1New Orleans, LA
    Welcome to New Orleans, world-renowned for its round-the-clock nightlife, vibrant live-music scene, and unique cuisine reflecting its history as a melting pot of French, African and American influences. This vivacious city is the perfect destination to begin your Mississippi River experience. Settle into your hotel and enjoy the city at your leisure.

    2Cruising the Mississippi River
    Board your ship and be treated to a Welcome Reception. Get to know your fellow guests and savor the view as you enjoy the afternoon rolling on the mighty Mississippi.

    3Baton Rouge, LA
    Meaning “red stick,” Baton Rouge’s 1699 French name references an ancient geographical marker and reflects the city’s long history. As Louisiana’s state capital, the city still echoes with tales of the characters who lived here, most notably Governor and Senator Huey P. Long. Learn about his dramatic career at the magnificent 1852 Old State Capitol Museum and visit Long’s 1932 State Capitol building, an architectural marvel of granite and marble.

    4Natchez, MS
    In Natchez, grand homes sparkle like jewels, adorning the bluffs that tower above the river. Since 1716, when the French first built a fort here among the Natchez Indians, the town has grown to boast elaborate mansions built by planters in the 1800s to flaunt their wealth. With no Civil War fighting here, Natchez still features hundreds of antebellum homes and buildings. Each of these architectural treasures has its own story to tell, creating a charming downtown that embodies the essence of southern charm and hospitality. Explore on your own or enjoy an array of curated, guided explorations. Tour the elaborate townhomes, visit a working cotton farm to learn about the crop’s importance in history and today, and discover the historic Under-The-Hill Saloon. Drift through quaint shops, nibble on local delights, and enjoy the expansive views of the majestic river valley from the bluff-top park.

    5Vicksburg, MS
    Vicksburg is a place of drama. During the Civil War, the struggle to control Vicksburg proved to be a major turning point. The well-fortified connection between river and rail transportation was known as “The Gibraltar of the West.” A narrated exploration of the well-preserved National Military Park battlefield enlivens this powerful story and highlights its significance. President Abraham Lincoln summarized Vicksburg’s importance clearly when he said, “Vicksburg is the key. The war can never be brought to a close until that key is in our pocket… They can defy us from Vicksburg… As valuable as New Orleans will be to us, Vicksburg will be more so.” Several other excursion options are available, including exploring museums and historic sites with local expert guides or on your own. Walk aboard an enormous Army Corps of Engineers towboat. Stroll along the charming series of murals painted along the adjacent floodwall and read panels detailing the Vicksburg stories they illustrate.

    6Day of River Cruising
    As we make our way from historic New Orleans to St. Louis, revel in the sights and sounds of the spectacular Mississippi River. Spend time chatting with other guests in the lounges or enjoy a cocktail on your private balcony.

    7Memphis, TN
    Welcome to Memphis, a historic city which rises picturesquely up the hillside from the river, adorned with grand oak trees, lush parks, and historic sites that commemorate everything from the Civil War to the Civil Rights Movement. Immerse yourself in its rich musical legacy as you stroll along legendary Beale Street, where music flows from every doorway, and savor the rich flavors and aromas of the city’s famous BBQ. Choose from an array of customized excursions. Perhaps take a narrated motorcoach excursion to get an overview of this dramatic city. Or indulge in the glamour of the Peabody Hotel. Explore the home, life, and career of Elvis Presley or make your pilgrimage to Sun Studio, where he recorded his earliest smash-hits.

    8New Madrid, MO
    Originally founded in 1776 by Spanish Governor Esteban Rodriguez, early settlers of New Madrid were required to become citizens of Spain in order to reside here. Today, New Madrid is a living monument to early American history with sites including the Kochtitzky Home, the Trail of Tears, and Veterans Park.

    9Paducah, KY
    Residing at the confluence of the Tennessee River and the Ohio River, Paducah will make you feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah’s rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library. Led by our expert guide, tour this enchanting city with a stop National Quilt Museum.

    10Day of River Cruising
    Sit back and enjoy the gentle sounds of the paddlewheel as it churns the placid waters of the Ohio River. One of the highlights of this cruise is the chance to watch the ever-changing scenery as it passes by and experience the river, as early explorers did centuries ago.

    11St. Louis, MO
    St. Louis is known as the “Gateway to the West." Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum.

    12St. Louis, MO
    On your travels back home, reflect on your wonderful memories.

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Cabin Categories

Cabin Single Price Double Price
Owner's Suite (Private Balcony)$11,085 pp
AAM (Private Balcony)$8,380 pp
AAC (Private Balcony)$7,880 pp
AAL (Private Balcony)$7,595 pp
AAR (Private Balcony)$7,160 pp
A$6,245 pp
Single (Private Balcony)$9,080
Single$8,215

Ship Read more about the American Heritage

*Prices may vary due to seasonality

Onboard Experience

The American Cruise Line fleet of ships are the newest and most environmentally friendly small ships in the US. The cruise line prides itself on their hospitable staff, and that you’ll be graciously received no matter which ship you cruise on. The large staterooms with interior entrances ensure you have a relaxed, private area to watch the river from, or visit any of the many onboard lounges. Daily entertainment will be brought onboard, including musicians, historians and naturalists.

Regionally-Inspired Menus

American Cruise Lines uses fresh, local ingredients to show off the culinary glory of the region you’re cruising in. On the Mississippi River, that could mean Andouille Gumbo, a po’boy with red beans and rice, and bourbon pecan pie. In New England, you could find Littleneck clam ceviche on the menu followed by a spiced apple pudding with maple whipped cream. In the Pacific Northwest, you’ll find fresh fish on the menu, including shrimp bisque or Dungeness Crab cake, and a marionberry cheesecake that’ll make your mouth water! Your ship will provide you with a list of all the locally-sourced ingredients when you unpack.

Eagle Society

Once you’ve cruised aboard any American Cruise Line ship, you are an Eagle Society member. It’s free to be a member, but your loyalty to American Cruise Lines is greatly rewarded. You’ll receive Eagle Society luggage tags, and member-only gifts when you board each cruise. After 3 cruises, you’ll receive complimentary premium shore excursions. After 10 cruises, you’ll get a complimentary 11th cruise. There are special Eagle Society cruise dates every year. Plus all Eagle Society member benefits can be used when booking with USA River Cruises, plus you’ll still be eligible for our loyal customer benefits as well.

Book Today

Mississippi River Gateway Cruise: New Orleans to St. Louis

Book Now Request More Info

or call 800.578.1479

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