Another vast and varied region of the world for which USA River Cruises has crafted an abundance of exciting, relaxing, exhilarating, peaceful (pick your adjective based on what you want from your trip) cruises. From Chesapeake Bay to the “Golden Isles” and from the “Great Rivers of Florida” to the Inland Passage, there is certainly something for just about everyone aboard one of our Southeast cruises.

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Let’s consider just one of our most popular excursions.

Historic South and Golden Isles

Our Historic South and Golden Isles trip is one of our favorites. And from what we can tell, it’s one of our customers’ favorites, too!

This eight-day trip heads from Jacksonville, Florida, to Charleston, South Carolina (or vice-versa). The Intracoastal Waterway is a series of protected bays, canals and rivers that make up a portion of the southeastern coast of the United States. The Golden Isles refers to a group of barrier islands off the coast of Georgia and the historic mainland city of Brunswick. The islands include St. Simons Island, Sea Island, Jekyll Island, and Little St. Simons Island.

There’s so much to see and do on this trip — which features many sites that are a part of American history. Plus, travelers can visit and explore amazing wildlife refuges of untouched beauty while partaking in southern hospitality, culture, and food.

Charleston, for example, is alive with history — everything from cobblestone streets and gas lamps to Civil War battlegrounds.

Stops also include gentle and genteel Savannah, Georgia, a historic city of 19th century architecture. Choose from one of many tour options, up to and including the National Museum of the Mighty Eighth Air Force and a guided walking tour of Savannah’s River Street section. And we haven’t even mentioned the ghost tours!

Thrills are easy to come by with USA River Cruises. Call us today to get started on yours!

Potomac River & Chesapeake Bay Cruise-American Liberty

Washtingon, DC to Baltimore

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Potomac River & Chesapeake Bay Cruise-American Eagle

Washtingon, DC to Baltimore

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East Coast Inland Passage – American Legend

Jacksonville to Baltimore

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East Coast Inland Passage-American Glory

Jacksonville, FL to Washington, DC

  • 14 Nights
  • April 2, 2025,October 31, 2025
  • From $10,585
  • American Glory
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Potomac River & Chesapeake Bay Cruise-American Glory

Washtingon, DC to Baltimore

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American Revolution Cruise-American Liberty

Roundtrip Washington, D.C.

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American Revolution Cruise – American Legend

Roundtrip Washington, D.C.

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American Revolution Cruise-American Glory

Roundtrip Washington, D.C.

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Grand Florida Coast & Keys Cruise- New 2025 Itinerary

St. Petersburg, FL to Jacksonville/Amelia Island, FL

  • 14 Nights
  • November 10, 2025,April 6, 2026,November 23, 2026
  • From $12,380
  • American Patriot
  • New Itinerary for 2025!!
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Grand Florida Coast & Keys Cruise- New 2025 Itinerary

  • 14 Nights
  • November 1, 2025,March 28, 2026,October 31, 2026
  • From $12,360
  • American Pioneer
  • New Itinerary for 2025!!
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Southeast Sea Islands Cruise-American Liberty

Charleston to Jacksonville

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East Coast Inland Passage – American Liberty

Jacksonville to Baltimore

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