Midwest River Cruises 2025 | USA River Cruises

Book ahead for our Fall Colors trip on the American Queen, which travels the Upper Mississippi, Ohio and Tennessee Rivers at the height of fall foliage. Want a novel holiday adventure for you and your family? Spend Thanksgiving or New Year’s aboard this luxurious small ship, the perfect mobile memory-maker.

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If you’ve heard the siren call of the Midwest, our cruise from Chicago through the Great Lakes to Rhode Island will bring you vistas and destinations large ships can’t reach. Enjoy rugged islands and stunning waterways along this peerless region of our fine country. Our agents are highly trained and as friendly as they come! We’re ready to craft the perfect cruise for you. Contact us with all of your questions. We’re so excited to get you onboard!

Mississippi Explorer Cruise-American Serenade

New Orleans, LA to Memphis, TN

11 Nights
October 30, 2025
From $7,770
American Serenade
New Itinerary for 2025!!

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Mississippi Explorer Cruise-American Symphony

New Orleans, LA to Memphis, TN

11 Nights
March 26, 2025,April 12, 2025
From $7,275
American Symphony

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Great Lakes Collection-Viking Octantis

Duluth, MN to Toronto, ON

14 Nights
May 20, 2025,June 3, 2025
From $14,495
Viking Octantis

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Mississippi River Odyssey- New Orleans to St. Paul

New Orleans, LA to St. Paul, MN

21 Nights
June 14, 2025,July 19, 2025,September 20, 2025
From $15,499
Viking Mississippi

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Ohio River Cruise- New 2025 Itinerary

Pittsburgh, PA (Or Reverse) to Louisville, KY

8 Nights
July 18, 2025,July 25, 2025,August 1, 2025--
9 more dates available.
From $4,610
American Heritage

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Ohio River Cruise- New 2025 Itinerary

Pittsburgh, PA (Or Reverse) to Louisville, KY

8 Nights
July 4, 2025,July 11, 2025,July 18, 2025--
7 more dates available.
From $5,275
American Melody

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Mississippi Delta Explorer

New Orleans, LA to Memphis, TN

7 Nights
January 11, 2025,January 18, 2025,January 25, 2025--
24 more dates available.
From $5,299
Viking Mississippi

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Niagara & the Great Lakes-Viking Polaris

Toronto to Milwaukee

7 Nights
May 5, 2025,May 12, 2025,May 19, 2025--
5 more dates available.
From $6,295
Viking Polaris

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The Tennessee Rivers Cruise

Chattanooga, TN to Nashville, TN

8 Nights
Please call for information on future dates.
From $5,190
American Melody

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Grand Ohio River-American Melody

Pittsburgh, PA to St. Louis, MO

15 Nights
June 20, 2025,August 15, 2025,June 19, 2026--
1 more date available.
From $9,015
American Melody

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Music Cities Cruise-American Symphony

Memphis, TN to Nashville, TN

8 Nights
April 22, 2025,August 5, 2025,August 12, 2025--
1 more date available.
From $4,910
American Symphony

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St. Lawrence Seaway and Great Lakes

Quebec City, QC to Milwaukee, WI

15 Nights
September 19, 2025,September 18, 2026
From $13,480
Pearl Mist

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