Sometimes the greatest adventures can be found just outside our own front doors. USA River Cruises offers trips that navigate the coastal waters, rivers, and inland waterways the world over. But some of the most popular and exciting trips take place in the vast nation that we call home: the United States of America.

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We encourage you to look through our U.S.A. offerings. The trips detailed on our website comprise many of the most phenomenal cruises we’ve put together for you. And since they take place right here in the U.S. of A., there’s less travel time involved in getting to the embarkation points, and more time to relax and travel the winding waterways of America.

Here are a few of our more popular offerings — but again we wish to stress how much we’d like you to look over all our offerings in order to tailor a trip that works best for you and your family.

There’s so much to choose from! Consider:

Grand Heartland Cruise: Cruise the length of the Mississippi River on a 14-night southbound trip that starts in St. Paul, Minnesota, and ends in the Big Easy (New Orleans, Louisiana). You’ll cruise down the mighty Mississippi and pass 10 states along the way!

Canyons, Glaciers & Waterfalls: This one’s actually a little off the beaten path — seeing as how it includes hotel stays and five nights aboard an Amtrak train! Visit so many sights and cities: Chicago, Los Angeles, the Grand Canyon (Arizona), Yosemite National Park, Glacier National Park, and more! Whew!

At USA River Cruises, we want to help you plan the trip of a lifetime — and to do it more than once! That’s right, </>all our trips can be considered trips of a lifetime. That’s how diverse, wide-ranging, and spectacular our itineraries are.

Each member of our team is passionate about traveling, and our strong dedication to customer service reflects our longstanding commitment that started the day we first opened our doors in 1996.

Contact USA River Cruises today to speak with a friendly, knowledgeable cruise agent. We want to help you “Imagine the Journey” — and then turn that imagination into reality.

Call us today. We’ll take care of everything.

Grand Florida Coast & Keys Cruise- New 2025 Itinerary

  • 14 Nights
  • November 1, 2025,March 28, 2026,October 31, 2026
  • From $12,360
  • American Pioneer
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Ohio River Cruise- New 2025 Itinerary

Pittsburgh, PA (Or Reverse) to Louisville, KY

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Ohio River Cruise- New 2025 Itinerary

Pittsburgh, PA (Or Reverse) to Louisville, KY

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Southeast Sea Islands Cruise-American Liberty

Charleston to Jacksonville

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Mississippi Delta Explorer

New Orleans, LA to Memphis, TN

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Niagara & the Great Lakes-Viking Polaris

Toronto to Milwaukee

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Yankee Seaports-American Independence

Boston, MA to New York City, NY

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Yankee Seaports-American Eagle

Boston, MA to New York City, NY

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The Tennessee Rivers Cruise

Chattanooga, TN to Nashville, TN

  • 8 Nights
  • Please call for information on future dates.
  • From $5,190
  • American Melody
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Grand Ohio River-American Melody

Pittsburgh, PA to St. Louis, MO

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New England Islands-American Liberty

Roundtrip Providence

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Music Cities Cruise-American Symphony

Memphis, TN to Nashville, TN

  • 8 Nights
  • August 5, 2025,August 12, 2025,October 28, 2025
  • From $4,910
  • American Symphony
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